Identification of the Key Genes Involved in the Tumorigenesis and Prognosis of Prostate Cancer

Figure 4

Validation of the gene expression levels of TOP2A, NCAPG, and BUB1B, by different datasets through various aspects. (a–c) TOP2A, NCAPG, and BUB1B gene expression levels between tumor and normal samples in the TCGA-PRAD dataset (internal validation dataset). (d–f) The correlation of TOP2A, NCAPG, and BUB1B with different Gleason scores (6, 7, 8, 9, and 10) in the TCGA-PRAD dataset (internal validation dataset). (g–i) The association between TOP2A, NCAPG, and BUB1B expressions and the different T stages (T2, T3, and T4) in the TCGA-PRAD dataset (internal validation dataset). (j–l) The expression of CCNA2, CKAP2L, NCAPG, and NUSAP1 in PCa samples with diverse T stages (N0, N1) in the TCGA-PRAD dataset (internal validation dataset). One-way analysis of variance (ANOVA) and Student’s -test was utilized to calculate statistical differences in these datasets.

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