Identification of the Key Genes Involved in the Tumorigenesis and Prognosis of Prostate Cancer

Figure 5

External validation of TOP2A, NCAPG, and BUB1B gene expression levels by different GEO datasets. (a) Gene expression levels of TOP2A, NCAPG, and BUB1B between PCa and normal samples in in the GSE32571 dataset. (b) TOP2A, NCAPG, and BUB1B gene expression differences between PCa and normal samples in the GSE70770 dataset. (c) Correlation of TOP2A, NCAPG and BUB1B with different Gleason scores (5, 6, 7, 8, 9, and 10) in the GSE70770 dataset. (d) Association between TOP2A, NCAPG, and BUB1B expressions and different T stages (T1, T2, and T3) in the GSE70770 dataset. Mann–Whitney and Kruskal-Wallis tests were utilized to calculate statistical differences in these datasets.

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