Integrated Bioinformatics and Experimental Analysis Identified TRIM28 a Potential Prognostic Biomarker and Correlated with Immune Infiltrates in Liver Hepatocellular Carcinoma

Table 1

Correlation between overall survival and multivariable characteristics in TCGA patients via Cox regression and multivariate survival model.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	373
≤60	177	Reference
>60	196	1.205 (0.850-1.708)	0.295	1.396 (0.855-2.281)	0.183
Gender	373
Female	121	Reference
Male	252	0.793 (0.557-1.130)	0.200	0.945 (0.574-1.555)	0.823
Histologic grade	368
G1 & G2	233	Reference
G3 & G4	135	1.091 (0.761-1.564)	0.636	0.968 (0.589-1.589)	0.897
Pathologic stage	349
Stage I & stage II	259	Reference
Stage III & Stage IV	90	2.504 (1.727-3.631)	<0.001	0.421 (0.023-7.620)	0.559
T stage	370
T1 & T2	277	Reference
T3 & T4	93	2.598 (1.826-3.697)	<0.001	6.493 (0.370-113.852)	0.200
M stage	272
M0	268	Reference
M1	4	4.077 (1.281-12.973)	0.017	1.790 (0.513-6.244)	0.361
N stage	258
N0	254	Reference
N1	4	2.029 (0.497-8.281)	0.324	3.099 (0.406-23.637)	0.275
TRIM28	373	1.578 (1.272-1.958)	<0.001	1.687 (1.252-2.275)	<0.001