Computational and Mathematical Methods in Medicine / 2022 / Article / Tab 2 / Research Article
Integrated Bioinformatics and Experimental Analysis Identified TRIM28 a Potential Prognostic Biomarker and Correlated with Immune Infiltrates in Liver Hepatocellular Carcinoma Table 2 Signaling pathways most significantly correlated with TRIM28 expression based on their normalized enrichment score (NES) and
value.
(a)
GO NAME NES NOM FDR Positive GO_APPENDAGE_DEVELOPMENT 2.415 0.001 0.031 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS 2.398 0.001 0.031 GO_APPENDAGE_MORPHOGENESIS 2.379 0.001 0.031 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT 2.314 0.002 0.032 GO_EMBRYONIC_APPENDAGE_MORPHOGENESIS 2.301 0.001 0.031 Negative GO_ORGANIC_ACID_CATABOLIC_PROCESS -3.277 0.016 0.079 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS -3.095 0.007 0.052 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS -3.062 0.006 0.046 GO_FATTY_ACID_CATABOLIC_PROCESS -3.045 0.006 0.048 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS -3.001 0.008 0.054
(b)
KEGG NAME NES NOM FDR Positive KEGG_RIBOSOME 2.301 0.001 0.036 KEGG_CELL_CYCLE 1.969 0.001 0.036 KEGG_DNA_REPLICATION 1.885 0.001 0.036 KEGG_PRIMARY_IMMUNODEFICIENCY 1.865 0.001 0.036 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 1.822 0.002 0.036 Negative KEGG_COMPLEMENT_AND_COAGULATION_CASCADES -2.972 0.004 0.038 KEGG_FATTY_ACID_METABOLISM -2.802 0.004 0.036 KEGG_PEROXISOME -2.795 0.005 0.040 KEGG_RETINOL_METABOLISM -2.683 0.005 0.038 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM -2.571 0.003 0.036
