PLK4 Is a Potential Biomarker for Abnormal Tumor Proliferation, Immune Infiltration, and Prognosis in ccRCC

Table 2

The correlation of PLK4 and immune cell gene markers in ccRCC by GEPIA.

Description	Gene markers	Purity cor.	value
Neutrophils	CD66b (CEACAM8)	0.05	0.25
	CD11b (ITGAM)	0.059	0.18
	CCR7	0.099	2.30-02
Dendritic cell	HLA-DPB1	0.16	1.90-04
	HLA-DQB1	0.13	3.90-03
	HLA-DRA	0.2	3.00-06
	HLA-DPA1	0.19	1.10-05
	BDCA-1 (CD1C)	0.065	0.14
	BDCA-4 (NRP1)	0.17	7.10-05
	CD11c	0.2	2.60-06
T cell (general)	CD3D	0.24	1.70-08
	CD3E	0.26	9.40-10
	CD2	0.32	2.90-14
CD8+ T cell	CD8A	0.3	2.20-12
	CD8B	0.24	2.70-08
TAM	CCL2	-0.1	1.80-02
	CD68	0.18	3.30-05
	IL10	0.2	5.80-06
Monocyte	CD86	0.31	2.20-13
	CD115 (CSF1R)	0.26	1.10-09
M1 macrophage	INOS (NOS2)	0.056	0.2
	IRF5	0.1	2.20-02
	COX2 (PTGS2)	0.025	0.58
M2 macrophage	CD163	0.28	1.60-10
	VSIG4	0.28	4.00-11
	MS4A4A	0.27	5.20-10
NK	KIR2DL1	-0.00032	0.99
	KIR2DL3	0.015	0.73
	KIR2DL4	0.12	6.70-03
	KIR3DL1	-0.013	0.77
	KIR3DL2	0.027	0.54
	KIR3DL3	0.053	0.23
	KIR2DS4	0.033	0.45
Tfh	BCL6	0.16	1.50-04
	IL21	0.27	5.20-10
Treg	FOXP3	0.24	3.80-08
	CCR8	0.3	4.00-12
	STAT5B	0.13	3.50-03
	TGFβ (TGFB1)	0.31	3.10-13
B cell	CD19	0.07	0.11
	CD79A	-0.007	0.87
Th1	T-bet (TBX21)	0.22	6.50-07
	STAT4	0.24	4.90-08
	STAT1	0.42	0
	IFN-γ (IFNG)	0.44	0
	TNF-α (TNF)	0.16	2.40-04
Th2	GATA3	0.19	7.20-06
	STAT6	0.15	6.40-04
	STAT5A	0.26	2.80-09
	IL13	0.027	0.54
Th17	STAT3	0.26	2.80-19
	IL17A	-0.03	0.5
T cell exhaustion	PD-1 (PDCD1)	0.34	6.70-16
	CTLA4	0.4	0
	LAG3	0.35	0
	TIM3 (HAVCR2)	0.016	0.72
	GZMB	0.33	4.00-15

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