Research Article

Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation

Figure 8

Working model for HDAC4- and HDAC5-mediated hypertrophy in AngII-induced atrial cardiomyopathy. Atrial cardiomyocytes have lower level of HDAC4 and HDAC5 enrichment on the promoter of chromatin of hypertrophy-related genes. After AngII induction, HDAC4 and HDAC5 shuttled from the nucleus to the cytoplasm. This results in loose chromatin structure and transcriptional induction of hypertrophy-related genes via deacetylation of chromatin histone and activation of the transcription factor MEF2, subsequently causing atrial hypertrophy.