[Retracted] G-Protein-Coupled Receptor Kinase-Interacting Protein 1 (GIT1) Promotes Head and Neck Squamous Cell Carcinoma Metastases via Activating the PI3K/AKT/mTOR Signal Pathway

Figure 5

GIT1 affected cell progression by regulating PIK3/AKT/mTOR pathway. (a) GIT1 knockdown diminished the protein expression level of p-P13K, p-Akt, and p-mTOR. GIT1 overexpression increased the protein expression level of p-PI3K, p-Akt, and p-mTOR compared with in control group. (b, c) GIT1 overexpression significantly promoted cell proliferation, while LY290004 weakened the effect of GIT1 on cell proliferation in HN8 and FaDu cells. (d) GIT1 overexpression obviously promoted cell migration ability, while LY290004 weakened the effect of GIT1 on cell migration ability in HN8 and FaDu cells. (e) GIT1 overexpression obviously promoted cell invasion ability, while LY290004 weakened the effect of GIT1 on cell invasion ability in HN8 and FaDu cells. (f) GIT1 overexpression obviously promoted EMT progression, while LY290004 weakened the effect of GIT1 on EMT progression in HN8 and FaDu cells. , compared with vector group; ^##, compared with GIT1 group.

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