Role of Long Noncoding RNAs in Smoking-Induced Lung Cancer: An In Silico Study

Figure 1

Differential expression of genes in lung cancer and effect of smoking on the prognosis of patients with lung cancer. (a) Genes obtained from The Cancer Genome Atlas (TCGA) dataset; blue denotes healthy subjects, pink represents patients with lung cancer, red represents positive association with high gene expression, and green represents negative association with low gene expression. The top 20 genes with the greatest positive and negative correlations were selected. (b) Genes obtained from the Gene Expression Omnibus (GEO) dataset, and others are similar to those in (a). (c) Volcano map of all differentially expressed genes identified through TCGA database; downregulated genes are indicated in green, and upregulated genes are indicated in red. (d) Differentially expressed genes identified in GEO. (e) The Venn diagram indicates the genes identified in TCGA and GEO databases. The differentially expressed genes are present in the intersection. Between the two databases, 562 differentially expressed genes were common. (f) Survival curve comparison for smoking and nonsmoking patients with lung cancer.

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