Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer

<div>miR-370 regulated the expression of MDM4. (a, b) circCCDC66-WT dramatically declined luciferase activities in HCT-116 and RKO cells. (c, d) The relative luciferase activity of MDM4-WT was uniquely alleviated by co-transfection with miR-370 mimic. (e) There was a positive correlation between CCDC66 and MDM4. (f) Knockdown of circCCDC66 significantly increased miR-370 expression. 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Computational and Mathematical Methods in Medicine

fig4

Figure 4

Figure 4: Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer 