Modeling and Mathematical Analysis of the Dynamics of HPV in Cervical Epithelial Cells: Transient, Acute, Latency, and Chronic Infections

Table 1

Parameters of epithelial cellular dynamics of healthy tissue and dynamics of HPV infection.

Parameter	Description	Value	Unit	Ranges	Ref
	Uninfected stratum basale cell proliferation rate				[25]
	Infected stratum basale cell proliferation rate				Fixed
	Uninfected stratum intermedium cell proliferation rate				[25]
	Infected stratum intermedium cell proliferation rate				Fixed
	Uninfected cell differentiation rate from stratum basale cell to stratum intermedium				[33]
	Infected cell differentiation rate from stratum basale cell to stratum intermedium				Fixed
	Uninfected cell differentiation rate from stratum intermedium cell to stratum corneum				[25]
	Infected cell differentiation rate from stratum intermedium cell to stratum corneum				[25]
	Uninfected basal cell natural death rate				[34]
	Infected basal cell death rate				[34]
	Desquamation rate of uninfected stratum corneum cells				[25]
	Desquamation rate of infected stratum corneum cells				Fixed
	Stratum basale cell carrying capacity		cells		[32]
	Stratum intermedium cell carrying capacity		cells		[32]
	Viral transmission rate	Varies			[25]
	Production rate of free virions	Varies			[11]
	Viral clearance rate				[25]

denotes ranges of values not evidenced in the literature.