Computational Modeling of T Cell Hypersensitivity during Coronavirus Infections Leading to Autoimmunity and Lethality

<div>Open-state SARS-CoV-2 (PDB ID: 6VYB) docked in the receptor CD147 (PDB ID: 3B5H) with crystallographic water molecules: (a) the best binding mode in the receptor, (b) in the mode number 6 along with side chains as lines, and (c) the twenty-two best binding modes showing amino acid residues involved in the interactions at 5 Å distance (receptor in cyan, ligand as dark blue sticks, Lys63 and Asp65 residues in magenta, and interactions as yellow dashes).</div>

Computational and Mathematical Methods in Medicine

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Figure 1

Figure 1: Computational Modeling of T Cell Hypersensitivity during Coronavirus Infections Leading to Autoimmunity and Lethality 