Computational and Mathematical Methods in Medicine

Computational Models of Articular Cartilage

Publishing date
17 May 2013
Submission deadline
30 Nov 2012

1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

2Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland

3Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB, Canada

4Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

Computational Models of Articular Cartilage


Prevention or slowing down the progression of osteoarthritis is a major challenge in health care. In osteoarthritis, articular cartilage degenerates and eventually wears out, resulting in pain and reduced joint function, ultimately leading to disability. The onset of osteoarthritis may result, for instance, from an injury of ligament, cartilage, or meniscus. However, the disease progression is patient specific and can hardly be predicted. In order to assess the articular cartilage function and possible failure sites in joints and to evaluate the osteoarthritis onset and progression, computational models have been and need to be further developed.

For any clinical application of a computer model, adequate investigation of the realistic properties of the cartilage tissue is needed. Current fibril-reinforced and biphasic models aim at mimicking articular cartilage structure and function. Cartilage models have been developed and employed to evaluate the mechanical behavior of cartilage at the cell, tissue, and joint levels, to evaluate static and dynamic tissue behavior, to explore effects of mechanical and biochemical loading, and to predict tissue remodeling, growth, and adaptation at the long time scale. The expectation is that such models may be taken to the next level, where patient-specific characteristics are incorporated in 3D models. Ultimately, they may then become clinical tools for predicting the progression of osteoarthritis and, thus, for identifying or optimizing patient-specific treatment strategies. These models could also be applied for the optimization of loading protocols in producing engineered cartilage as repair materials.

The purpose of this special issue is to present new theoretical developments in articular cartilage modeling at the cell, tissue, and joint levels. We are interested in multiscale models, models of cell-tissue interactions, matrix growth, and disease progression. Manuscripts investigating model validation are highly encouraged. We will also consider other fibrous skeletal soft tissue models, provided that they present the most recent advancements in the field. Potential topics include, but are not limited to:

  • Constitutive modeling of articular cartilage
  • Chondrocyte deformation
  • Cell-tissue interaction
  • Matrix growth and synthesis
  • Knee/hip/ankle joint models
  • Fibrous skeletal soft tissue models
  • Modelling cartilage tissue engineering and repair
  • Modeling in diagnostics of osteoarthritis
  • Adaptive models of skeletal soft tissues

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 254507
  • - Editorial

Computational Models of Articular Cartilage

Rami K. Korhonen | Petro Julkunen | ... | Corrinus C. van Donkelaar
  • Special Issue
  • - Volume 2013
  • - Article ID 326150
  • - Review Article

A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading

Petro Julkunen | Wouter Wilson | ... | Rami K. Korhonen
  • Special Issue
  • - Volume 2013
  • - Article ID 358192
  • - Research Article

Further Insight into the Depth-Dependent Microstructural Response of Cartilage to Compression Using a Channel Indentation Technique

Ashvin Thambyah | Neil D. Broom
  • Special Issue
  • - Volume 2013
  • - Article ID 164146
  • - Research Article

Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis

Petri Tanska | Siru M. Turunen | ... | Rami K. Korhonen
  • Special Issue
  • - Volume 2013
  • - Article ID 718423
  • - Review Article

Recent Advances in Computational Mechanics of the Human Knee Joint

M. Kazemi | Y. Dabiri | L. P. Li
  • Special Issue
  • - Volume 2013
  • - Article ID 862903
  • - Research Article

Altered Knee Joint Mechanics in Simple Compression Associated with Early Cartilage Degeneration

Y. Dabiri | L. P. Li
  • Special Issue
  • - Volume 2012
  • - Article ID 767469
  • - Research Article

Reliability of Semiautomated Computational Methods for Estimating Tibiofemoral Contact Stress in the Multicenter Osteoarthritis Study

Donald D. Anderson | Neil A. Segal | ... | John A. Lynch
Computational and Mathematical Methods in Medicine
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