Is Subcutaneous Route an Alternative to Intravenous Route for Mouse Contrast-Enhanced Magnetic Resonance Imaging at 1.5 T?

Table 2

Dotarem and Vasovist MRI contrast agent characteristics [10].

Contrast agent (trade name)	Dotarem	Vasovist
Molecule name	Gadoterate meglumine	Gadofosveset trisodium
Acronym	Gd-DOTA	MS-325
Manufacturer	Guerbet	Bayer Schering
Human body region(s) approved	CNS, whole body	Vessels
Approved dose (mmol/kg)	0.1 – 0.3	0.03
Concentration	0.5 mol/L	0.25 mol/L
Charge	Ionic	Ionic
Molecular structure	Cyclic	Linear
Osmolality (mOsm/kg H2O at 37°C)	1350	825
Viscosity (mPa.s at 37°C)	2.0	2.1
Plasmatic relaxivities (r1/r2 1.5T in L.mmol^−1.s^−1)	(3.4-3.8)/(3.4-5.2)	(18-20)/(32-36)