Research Article
HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks
Algorithm 5
The dynamic reaction partitioning of HRSSA (please refer to [
21] for details).
Input: The same as RSSA (Algorithm 2) together with the time granularity used for the | (approximate) simulation of fast reactions; the minimum amount of molecules that | has to be available for fast reactions; the minimum number of times that a fast | reaction has to be applied, in average, within the time range of size . | Output: the sets and of slow and fast reactions, respectively. | Pseudocode: | ; ; | for each reaction | if then | Put reaction in the set ; | else if , modified by with stoichiometric coefficient , such that | then | Put reaction in the set ; | else | Put reaction in the set ; | end if | end for |
|