Robust Nonnegative Matrix Factorization via Joint Graph Laplacian and Discriminative Information for Identifying Differentially Expressed Genes

Table 2

Pancreatic cancer genes extracted by GLD-RNMF.

Gene ID	Gene name	Gene annotations	Relative diseases
4313	MMP2	Serine-type endopeptidase activity and metallopeptidase activity	Arthropathy and multicentric osteolysis of Torg
3486	IGFBP3	Fibronectin binding and insulin-like growth factor I binding.	Insulin-like growth factor I and acromegaly
3630	INS	Identical protein binding and protease binding	Diabetes mellitus
4316	MMP7	Peptidase activity and metallopeptidase activity	Spastic entropion and focal myositis
3880	KRT19	Structural molecule activity and structural constituent of cytoskeleton	Thyroid cancer and lung cancer
7057	THBS1	Calcium ion binding and heparin binding	Posterior uveal melanoma and thrombotic thrombocytopenic purpura
3320	HSP90AA1	Poly(A) RNA binding and identical protein binding	Lobular neoplasia and candidiasis
1508	CTSB	Peptidase activity and cysteine-type peptidase activity	Occlusion of gallbladder and ileum cancer
7076	TIMP1	Cytokine activity and protease binding.	Oral submucous fibrosis and lung giant cell carcinoma
2335	FN1	Heparin binding and protease binding	Glomerulopathy and plasma fibronectin deficiency