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Volume 2017, Article ID 5436737, 9 pages
Research Article

Formation of Autapse Connected to Neuron and Its Biological Function

1Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China
2NAAM-Research Group, Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
3College of science, China University of Mining and Technology, Xuzhou 221116, China

Correspondence should be addressed to Jun Ma; moc.361@soahcrepyh

Received 9 September 2016; Revised 4 January 2017; Accepted 17 January 2017; Published 28 February 2017

Academic Editor: Mattia Frasca

Copyright © 2017 Chunni Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Autapse is a specific synapse connected to the neuron via close loop, and its functional adjusting is described by applying time-delayed feedback on the membrane potential of the neuron. This paper discussed the possible formation mechanism and biological function of autapse connection on neurons. We believe that the formation and growth of autapse connected to neuron can be associated with injury on axon and blocking in signal transmission; thus auxiliary loop is developed to form an autapse. When autapse is set up, it can propagate the signals and change the modes of electrical activities under self-adaption. Based on the cable neuron model, the injury on axon is generated by poisoning and blocking in ion channels (of sodium); thus the conductance of ion channels are changed to form injury-associated defects. Furthermore, auxiliary loop with time delay is designed to restore and enhance signal propagation by setting different time delays and feedback gains. The numerical studies confirmed that appropriate time delay and feedback gain in electric or chemical autapse can help signal (or wave generated by external forcing) propagation across the blocked area. As a result, formation of autapse could be dependent on the injury of neuron and further enhances the self-adaption to external stimuli.