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Volume 2018, Article ID 1589016, 10 pages
Research Article

Congenital and Blood Transfusion Transmission of Chagas Disease: A Framework Using Mathematical Modeling

1Universidade Federal Rural de Pernambuco, Departamento de Estatística e Informática, Recife, PE, Brazil
2LIKA –Laboratório de Imunopatologia Keizo Assami, UFPE, Recife, PE, Brazil
3FIOCRUZ – Fundação Oswaldo Cruz - Pernambuco, Recife, Brazil
4Unitat de Salut Internacional, PROSICS, Programa Especial de Malalties Infeccioses Vall d’Hebron-Drassanes, Barcelona, Spain
5Universitat Politècnica de Catalunya BarcelonaTech, Departament de Física, Escola Superior d’Agricultura de Barcelona, Castelldefels, Spain

Correspondence should be addressed to Clara Prats; ude.cpu@starp.aralc

Received 21 May 2018; Accepted 4 October 2018; Published 1 November 2018

Guest Editor: Miguel Fuentes

Copyright © 2018 Edneide Ramalho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chagas disease or American trypanosomiasis is an important health problem in Latin America. Due to the mobility of Latin American population around the world, countries without vector presence started to report disease cases. We developed a deterministic compartmental model in order to gain insights into the disease dynamics in a scenario without vector presence, considering congenital transmission and transmission by blood transfusion. The model was used to evaluate the epidemiological effect of control measures. It was applied to demographic data from Spain and sensitivity analysis was performed on model parameters associated with control strategies.