Complexity

Dynamical Analysis of Biological Systems


Publishing date
01 Sep 2020
Status
Closed
Submission deadline
24 Apr 2020

1Mississippi State University, Starkville, USA

2Georgia Institute of Technology, Atlanta, USA

3Politehnica University of Bucharest, Bucharest, Romania

This issue is now closed for submissions.
More articles will be published in the near future.

Dynamical Analysis of Biological Systems

This issue is now closed for submissions.
More articles will be published in the near future.

Description

A fundamental challenge in computational biology is to understand the complex dynamics of biological systems, and system-level approaches that combine high-throughput experimental data with mathematical and computational modeling are emerging as a comprehensive way to study these systems’ dynamics. Biological processes involve complexes of proteins whose interaction characteristics, such as randomness of duration and of interaction timing, are best captured by stochastic models, and a common modeling approach is the use of systems of stochastic differential equations that describe the evolution of the biochemical reaction networks. Stochastic simulation and stochastic control have been recently used to infer cellular networks structure, to study cell decisions and to understand complex dynamics of biological processes.

Noise is an intrinsic aspect in the dynamics of biochemical networks. While solving the dynamics of biochemical reactions at equilibrium, many random effects that cannot be modeled may affect the analysis of nonlinear dynamics of large biochemical reaction networks. Recent work has generated new insights into the complex dynamics of biological systems and the control processes that drive their dynamics.

The aim of this special issue is to attract original research contributions and comprehensive reviews on dynamical systems analysis, stochastic modeling, and control theory focusing on methods for dynamical systems analysis (stochastic differential equations, bifurcation analysis and chaotic behavior, and multitime stochastic methods), modeling and analysis of biological systems (developmental dynamics, cellular differentiation, and immune system dynamics), and control of biological processes (stochastic control analysis, cell decision processes, transcription, translation, and epigenetic control).

We encourage submissions of theoretical as well as applied investigations on the dynamical analysis of biological systems, bifurcation analysis, and chaotic behavior in biological systems, network dynamics analysis, stochastic reaction networks with time-scale separation, and numerical methods for simulations and analysis of biological networks.

Potential topics include but are not limited to the following:

  • Dynamical systems and systems biology
  • Bifurcation analysis in biological systems
  • Chaotic behavior in biological systems
  • Stochastic differential equations for analysis of biological systems
  • Dynamics of cellular process using time-varying multiscale models
  • Multitime methods for system dynamics analysis
  • Multitime evolution and optimal control in biological systems
  • Numerical methods for computation of steady-state dynamics
  • Numerical methods for large scale simulations of biochemical networks dynamics

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 6402703
  • - Research Article

Dynamical Regulation of mRNA Distribution by Cross-Talking Signaling Pathways

Chunjuan Zhu | Guosheng Han | Feng Jiao
  • Special Issue
  • - Volume 2020
  • - Article ID 8536365
  • - Research Article

Optimal Design of Single-Cell Experiments within Temporally Fluctuating Environments

Zachary R. Fox | Gregor Neuert | Brian Munsky
  • Special Issue
  • - Volume 2020
  • - Article ID 5163704
  • - Research Article

A Nonoscillatory Second-Order Time-Stepping Procedure for Reaction-Diffusion Equations

Philku Lee | George V. Popescu | Seongjai Kim
  • Special Issue
  • - Volume 2020
  • - Article ID 5049825
  • - Research Article

Mathematical Model Analysis and Simulation of Visceral Leishmaniasis, Kashgar, Xinjiang, 2004–2016

Yateng Song | Tailei Zhang | ... | Xiaobo Lu
  • Special Issue
  • - Volume 2020
  • - Article ID 8428269
  • - Research Article

Periodic Solution of a Neutral Delay Leslie Predator-Prey Model and the Effect of Random Perturbation on the Smith Growth Model

Tongtong Li | Wencai Zhao
  • Special Issue
  • - Volume 2020
  • - Article ID 6403641
  • - Research Article

Separable Nonlinear Least-Squares Parameter Estimation for Complex Dynamic Systems

Itai Dattner | Harold Ship | Eberhard O. Voit
  • Special Issue
  • - Volume 2020
  • - Article ID 3687961
  • - Research Article

The Dynamics of Canalizing Boolean Networks

Elijah Paul | Gleb Pogudin | ... | Reinhard Laubenbacher
  • Special Issue
  • - Volume 2020
  • - Article ID 1947809
  • - Research Article

Global Attractivity for Lasota–Wazewska-Type System with Patch Structure and Multiple Time-Varying Delays

Zhiwen Long | Yanxiang Tan
  • Special Issue
  • - Volume 2020
  • - Article ID 8763126
  • - Research Article

Modeling Periodic HFMD with the Effect of Vaccination in Mainland China

Lei Shi | Hongyong Zhao | Daiyong Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 4760297
  • - Research Article

Walking Gait Phase Detection Based on Acceleration Signals Using Voting-Weighted Integrated Neural Network

Lei Yan | Tao Zhen | ... | Xiao-Lei Zhou
Complexity
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Acceptance rate43%
Submission to final decision64 days
Acceptance to publication35 days
CiteScore3.200
Impact Factor2.462
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