Table of Contents
Conference Papers in Medicine
Volume 2013 (2013), Article ID 159570, 20 pages
http://dx.doi.org/10.1155/2013/159570
Conference Paper

Essentials of Oncothermia

Department of Biotechnics, Szent Istvan University, Pater K. u. 1., Godollo 2100, Hungary

Received 17 January 2013; Accepted 17 April 2013

Academic Editors: G. F. Baronzio, M. Jackson, D. Lee, and A. Szasz

This Conference Paper is based on a presentation given by Oliver Szasz at “Conference of the International Clinical Hyperthermia Society 2012” held from 12 October 2012 to 14 October 2012 in Budapest, Hungary.

Copyright © 2013 Oliver Szasz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. H. Seegenschmiedt and C. C. Vernon, “A historical perspective on hyperthermia in oncology,” in Thermoradiotherapy and Thermochemotherapy. vol. 2: Clinical Applications, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon, Eds., pp. 3–46, Springer, Berlin, Germany, 1995. View at Google Scholar
  2. P. W. Vaupel and D. K. Kelleher, “Metabolic status and reaction to heat of normal and tumor tissue,” in Thermo-Radiotherapy and Thermo-Chemiotherapy. Biology, Physiology and Physics, M.-H. Seegenschmiedt, P. Fessenden, and C. C. Vernon, Eds., vol. 1, pp. 157–176, Springer, Berlin, Germany, 1996. View at Google Scholar
  3. W. Busch, “Uber den Einfluss welche heftigere Erysipein zuweilig auf organisierte Neubildungenausuben,” Verhandlungen des Naturhistorischen Vereins der Preußischen Rheinlande und Westphalens, vol. 23, pp. 28–30, 1866. View at Google Scholar
  4. C. Muller, “Therapeutische Erfahrungen an 100 mit kombination von Rontgenstrahlen un Hochfrequenz, resp. Diathermie behandeleten bosartigen Neubildungen,” Munchener Medizinische Wochenschrift, vol. 28, pp. 1546–1549, 1912. View at Google Scholar
  5. K. H. Bauer, Das Krebsproblem: einführung in die allgemeine Geschwulstlehre für Studierende, Ärzte und Naturwissenschaftler, Springer, Berlin, Germany, 1949.
  6. H. H. LeVeen, S. Wapnick, V. Piccone, G. Falk, and Ahmed Nafis, “Tumor eradication by radiofrequency therapy. Responses in 21 patients,” Journal of the American Medical Association, vol. 235, no. 20, pp. 2198–2200, 1976. View at Publisher · View at Google Scholar · View at Scopus
  7. J. G. Short and P. F. Turner, “Physical hyperthermia and cancer therapy,” Proceedings of the IEEE, vol. 68, no. 1, pp. 133–142, 1980. View at Google Scholar · View at Scopus
  8. F. K. Storm, D. L. Morton, L. R. Kaiser et al., “Clinical radiofrequency hyperthermia: a review,” National Cancer Institute Monograph, vol. 61, pp. 343–350, 1982. View at Google Scholar · View at Scopus
  9. S. Jo, T. Sugahara, and I. Yamamoto, “Clinical response of hyperthermia using heating equipment Thermotron-RF8 in Japan,” Biomedical Engineering—Applications, Basis and Communications, vol. 6, no. 3, pp. 340–362, 1994. View at Google Scholar · View at Scopus
  10. Y. Hiraki and M. Nakajo, “Effectiveness of RF capacitive hyperthermia combined with radiotherapy for Stages III and IV oro-hypopharyngeal cancers: a nonrandomized comparison between thermoradiotherapy and radiotherapy,” International Journal of Hyperthermia, vol. 14, no. 6, pp. 593–594, 1998. View at Google Scholar · View at Scopus
  11. Y. Harima, K. Nagata, K. Harima et al., “Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in stage IIIB cervical carcinoma,” Cancer, vol. 88, no. 1, pp. 132–138, 2000. View at Google Scholar
  12. C. K. Lee, C. W. Song, J. G. Rhee, J. A. Foy, and S. H. Levitt, “Clinical experience using 8 MHz radiofrequency capacitive hyperthermia in combination with radiotherapy: results of a phase I/II study,” International Journal of Radiation Oncology Biology Physics, vol. 32, no. 3, pp. 733–745, 1995. View at Publisher · View at Google Scholar · View at Scopus
  13. S. I. Masunaga, M. Hiraoka, K. Akuta et al., “Phase I/II trial of preoperative thermoradiotherapy in the treatment of urinary bladder cancer,” International Journal of Hyperthermia, vol. 10, no. 1, pp. 31–40, 1994. View at Google Scholar · View at Scopus
  14. T. F. Weiss, Cellular Biophysics, Bradford Book, MIT Press, Cambridge, Mass, USA, 1996.
  15. R. W. Rand, H. D. Snow, and W. J. Brown, “Thermomagnetic surgery for cancer,” Journal of Surgical Research, vol. 33, no. 3, pp. 177–183, 1982. View at Google Scholar · View at Scopus
  16. H. Matsuki, T. Satoh, K. Murakami, T. Hoshino, T. Yanada, and S. Kikuchi, “Local hyperthermia based on soft heating method utilizing temperature-sensitive ferrite rod,” IEEE Transactions on Magnetics, vol. 26, no. 5, pp. 1551–1553, 1990. View at Publisher · View at Google Scholar · View at Scopus
  17. R. K. Gilchrist, R. Medal, W. D. Shorey, R. C. Hanselman, J. C. Parrott, and C. B. Taylor, “Selective inductive heating of lymph nodes,” Annals of Surgery, vol. 146, no. 4, pp. 596–606, 1957. View at Google Scholar
  18. J. R. N. Oleson, “The role of magnetic inductiontechniques for producing hyperthermia,” in Hyperthermia in Cancer Treatment, L. J. Anghileri and J. Robert, Eds., vol. 2, pp. 141–154, CRC Press, Boca Roton, Fla, USA, 1985. View at Google Scholar
  19. S. Nishide and S. Ueno, “Method of localized hyperthermia by using a figure-of-eight coil and short-circuit rings,” in Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 1447–1448, October 1993. View at Scopus
  20. M. Jojo, A. Murakami, F. Sato, H. Matsuki, and T. Sato, “Consideration of handy excitation apparatus for the inductive hyperthermia,” IEEE Transactions on Magnetics, vol. 37, no. 4 I, pp. 2944–2946, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Jordan, R. Scholz, P. Wust, H. Fähling, and R. Felix, “Magnetic fluid hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles,” Journal of Magnetism and Magnetic Materials, vol. 201, no. 1-3, pp. 413–419, 1999. View at Google Scholar · View at Scopus
  22. L. S. Taylor, “Devices for microwave hyperthermia,” in Cancer Therapy by Hyperthermia and Radiation, C. Streffer, D. vanBeuningen, and F. Dietzel, Eds., pp. 115–121, Urban & Schwarzenberg, Baltimore, Md, USA, 1978. View at Google Scholar
  23. P. F. Turner, “Regional hyperthermia with an annular phased array,” IEEE Transactions on Biomedical Engineering, vol. 31, no. 1, pp. 106–111, 1984. View at Google Scholar · View at Scopus
  24. D. Gonzalez-Gonzalez, J. D. P. van Dijk, and F. Oldenburger, “Results of combined treatment with radiation and hyperthermia in 111 patinets with large of deep-seated tumors,” in Hyperthermia Oncology, E. W. Germeg, Ed., vol. 1, p. 415, Ticson, Ariz, USA, 1992. View at Google Scholar
  25. R. J. Myerson, L. Leybovich, B. Emami, P. W. Grigsby, W. Straube, and D. Von Gerichten, “Phantom studies and preliminary clinical experience with the BSD 2000,” International Journal of Hyperthermia, vol. 7, no. 6, pp. 937–951, 1991. View at Google Scholar · View at Scopus
  26. P. Wust, H. Fähling, W. Wlodarczyk et al., “Antenna arrays in the SIGMA-eye applicator: interactions and transforming networks,” Medical Physics, vol. 28, no. 8, pp. 1793–1805, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Wust, R. Felix, and P. Deuflhard, “Kunstliches fieber gegen krebs,” Spektrum der Wissenschaft, pp. 78–84, 1999. View at Google Scholar
  28. R. Issels, “Hyperthermia combined with chemotherapy—biological rationale, clinical application, and treatment results,” Onkologie, vol. 22, no. 5, pp. 374–381, 1999. View at Google Scholar · View at Scopus
  29. R. D. Issels, S. Abdel-Rahman, C. M. Wendtner et al., “Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study,” European Journal of Cancer, vol. 37, no. 13, pp. 1599–1608, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Wust, B. Hildebrandt, G. Sreenivasa et al., “Hyperthermia in combined treatment of cancer,” Lancet Oncology, vol. 3, no. 8, pp. 487–497, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. S. A. Shah, R. K. Jain, and P. L. Finney, “Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma,” Cancer Letters, vol. 19, no. 3, pp. 317–323, 1983. View at Google Scholar · View at Scopus
  32. S. D. Nathanson, L. Nelson, P. Anaya, S. Havstad, and F. W. Hetzel, “Development of lymph node and pulmonary metastases after local irradiation and hyperthermia of footpad melanomas,” Clinical and Experimental Metastasis, vol. 9, no. 4, pp. 377–392, 1991. View at Google Scholar · View at Scopus
  33. R. S. Oliveira-Filho, R. G. Bevilacqua, and R. Chammas, “Hyperthermia increases the metastatic potential of murine melanoma,” Brazilian Journal of Medical and Biological Research, vol. 30, no. 8, pp. 941–945, 1997. View at Google Scholar · View at Scopus
  34. F. K. Storm, “What happened to hyperthermia and what is its current status in cancer treatment?” Journal of Surgical Oncology, vol. 53, no. 3, pp. 141–143, 1993. View at Google Scholar · View at Scopus
  35. O. S. Nielsen, M. Horsman, and J. Overgaard, “A future for hyperthermia in cancer treatment?” European Journal of Cancer, vol. 37, no. 13, pp. 1587–1589, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. W. R. Smythe and P. F. Mansfield, “Hyperthermia: has its time come?” Annals of Surgical Oncology, vol. 10, no. 3, pp. 210–212, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Van Der Zee, D. González González, G. C. Van Rhoon, J. D. P. Van Dijk, W. L. J. Van Putten, and A. A. M. Hart, “Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial,” Lancet, vol. 355, no. 9210, pp. 1119–1125, 2000. View at Google Scholar · View at Scopus
  38. P. R. Stauffer, “Evolving technology for thermal therapy of cancer,” International Journal of Hyperthermia, vol. 21, no. 8, pp. 731–744, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Vasanthan, M. Mitsumori, J. H. Park et al., “Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a multi-institutional prospective randomized trial of the international atomic energy agency,” International Journal of Radiation Oncology Biology Physics, vol. 61, no. 1, pp. 145–153, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Szasz, “What is against the acceptance of hyperthermia?” Die Naturheilkunde Forum-Medizine, vol. 83, pp. 3–7, 2006. View at Google Scholar
  41. J. Gellermann, W. Wlodarczyk, B. Hildebrandt et al., “Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 tesla hybrid system,” Cancer Research, vol. 65, no. 13, pp. 5872–5880, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Gellerman, “Nichtinvasive thermometrie bei lokoregionaler tiefenhyperthermie Invited presenation,” Key-note, Hyperthermia Seminar, Cologne, Germany, 2006.
  43. W. Wlodarczyk, P. Wust, M. Seebass, J. Gellermann, and J. Nadobny, “Recent advances in technology and technique of rf hyperthermia,” Charite University Clinic, Berlin, Germany, 2012, www.ursi.org/Proceedings/ProcGA02/papers/p0835.pdf.
  44. P. Wust and J. Gellermann, “Nichtinvasives MR-monitoring von weichteilsarkom en unter regionale Hyperthermie,” http://ebookbrowse.com/wust-gellermann-20-5-08-pdf-d67803854.
  45. J. Gellermann, B. Hildebrandt, R. Issels et al., “Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia: correlation with response and direct thermometry,” Cancer, vol. 107, no. 6, pp. 1373–1382, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. “Brochure of Thermotron RF-8,” Yamamoto Vinita, Osaka, Japan.
  47. P. H. Sugarbaker, C. Siugarbeker, and D. Chang, “Radiofrequency hyperthermia alone in the palliative treatment of mucinous carcinomatosis: optimizing and monitoring heat delivery,” in Thermotherapy for Neoplasia, Inflammation, and PaIn, M. Kosaka, T. Sugahara, K. L. Schmidt, and E. Simon, Eds., pp. 456–463, Springer, Tokyo, Japan, 2001. View at Google Scholar
  48. S. Osinsky, V. Ganul, V. Protsyk et al., “Local and regional hyperthermia in combined treatment of malignant tumors: 20 years experience in Ukraine,” in Proceedings of the The Kadota Fund International Forum, Awaji, Japan, June 2004.
  49. J. van der Zee, Presentation on Conference in Mumbai, India, 2005, http://www.google.com/#sclient=psy&hl=en&site=&source=hp&q=%22van+der+Zee%22+Mumbai+ext:ppt&btnG=Google+Search&aq=&aqi=&aql=&oq=&pbx=1&bav=on. 2, or.r_gc.r_pw.&fp=e7df6ea8d325b7b2.
  50. D. Fatehi, J. Van der Zee, E. Van der Wal, W. N. Van Wieringen, and G. C. Van Rhoon, “Temperature data analysis for 22 patients with advanced cervical carcinoma treated in Rotterdam using radiotherapy, hyperthermia and chemotherapy: a reference point is needed,” International Journal of Hyperthermia, vol. 22, no. 4, pp. 353–363, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Dani and A. Varkonyi, “Electro-hyperthermia treatment of malignant brain tumors,” in Proceedings of the Results of Hyperthermia Seminar, St. Istvan University, August 2003.
  52. A. Szasz, A. Dani, and A. Varkonyi, “Az elektro-hipertermia eredményei nagyszámú beteg retrospektív kiértékelésének tükrében Magyarországon,” in Magyar Klinikai Onkológiai Társaság III. Kongresszusa, Budapest, Hungary, November 2004.
  53. A. Szasz, “Agydaganatok elektro-hipertermiája. Retrospektiv klinikai vizsgálat 155 német beteg bevonásával,” in 25th Magyar Onkológusok Társasága. Kongresszusa, Budapest, Romania, November 2005.
  54. H. Sahinbas, D. H. W. Grönemeyer, E. Böcher, and A. Szasz, “Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas,” Deutsche Zeitschrift für Onkologie, vol. 39, no. 4, pp. 154–160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Szasz, N. Szasz, and O. Szasz, Oncothermia—Principles and Practices, Springer, Heidelberg, Germany, 2010.
  56. A. Szasz, “Brain glioma results by oncothermia, a review,” in Proceedings of the Annual Meeting of Society of Thermal Medicine Expanding the Frontiers of Thermal Biology, Medicine and Physics, Tucson, Ariz, USA, April 2009.
  57. F. Douwes, O. Douwes, F. Migeod, C. Grote, and J. Bogovic, “Hyperthermia in combination with ACNU chemotherapy in the treatment of recurrent glioblastoma,” 2006, http://www.klinikst-georg.de/pdf/hyperthermia_in_combination_with_ACNU_chemotherapy_in_the_treatment_of_recurrent_glioblastoma.pdf.
  58. D. Hager, H. Dziambor, E. M. App, C. Popa, O. Popa, and M. Hertlein, “The treatment of patients with high-grade malignant gliomas with RF-hyperthermia,” in Proceedings of the 39th American Society of Clinical Oncology Annual Meeting, vol. 22, Chicago, Ill, USA, abstract 47, 2003.
  59. E. D. Hager, H. Sahinbas, D. H. Groenemeyer, and F. Migeod, “Prospective phase II trial for recurrent high-grade malignant gliomas with capacitive coupled low radiofrequency (LRF) deep hyperthermia,” Journal of Clinical Oncology, vol. 26, abstract 2047, Proceedings of the American Society of Clinical Oncology Annual Meeting, 2008.
  60. G. Fiorentini, P. Giovanis, S. Rossi et al., “A phase II clinical study on relapsed malignant gliomas treated with electro-hyperthermia,” In Vivo, vol. 20, no. 6 A, pp. 721–724, 2006. View at Google Scholar · View at Scopus
  61. G. Baronzio and G. Fiorentini, “Relapsed malignant gliomas treated with electro-hyperthermia: report of 24 casdes,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  62. C. Wismeth, S. Ganbauer, P. Hau et al., “Loco-regional hyperthermia in patients with progressive astrocytoma WHO III or glioblastoma WHO IV, (RNOP-10)—a prospective single arm phase I/II study,” in Proceedings of the 7th Meeting of the European Association for NeuroOncology (EANO '06), Vienna, Austria, abstract P153, poster board PB134, September 2006.
  63. P. Hau, “Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: phase I clinical results,” in Proceedings of the 1st International Oncothermia Symposium, Cologne, Germany, November 2010.
  64. Wismeth c, B. Hirschmann, C. Pascher et al., “Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsing high-grade gliomas-phase I clinical results,” in Proceedings of the Expanding the Frontiers of Thermal Biology, Medicine and Physics Annual Meeting of Society of Thermal Medicine, Tucson, Ariz, USA, April 2009.
  65. C. Wismeth, C. Dudel, C. Pascher et al., “Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: phase i clinical results,” Journal of Neuro-Oncology, vol. 98, no. 3, pp. 395–405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  66. A. Szasz, A. Dani, A. Varkonyi, and T. Magyar, “Retrospective analysis of 1180 oncological patients treated by electrohyperthermia in Hungary,” in Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO '11), Karlsruhe, Germany, May 2005.
  67. H. Aydin et al., “Strahlen-Hyperthermie bei Lebermetastasen und bei therapieresistenten Knochenmetastasen,” in Proceedings of the Hyperthermia Symposium, Cologne, Germany, October 2003.
  68. A. Dani, A. Varkonyi, T. Magyar, and A. Szasz, “Clinical study for advanced non-small-cell lung cancer treated by oncothermia,” Oncothermia Journal, vol. 3, pp. 39–49, 2011. View at Google Scholar
  69. D. Y. Lee, H. C. Paik, and S. J. Haam, “Hyperthermia in the patients with small cell lung cancer,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  70. A. Szasz, A. Dani, A. Varkonyi, and T. Magyar, “Retrospective analysis of 1180 oncological patients treated by electrohyperthermia in Hungary,” in Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO '11), Karlsruhe, Germany, May 2005.
  71. A. Dani, A. Varkonyi, T. Magyar, and A. Szasz, “A retrospective study of 1180 cancer patients treated by oncothermia,” Forum Hyperthermia. In press.
  72. H. Renner, “Simultane radio thermotherapie bzw,” in Proceedings of the RadioChemoThermoTherapie, Hyperthermia Symposium, Cologne, Germany, October 2003.
  73. A. Szasz, “Clinical studies evidences of modulated rf-conductive heating (mEHT) method,” in Proceedings of the 25th Annual Meeting of the European Society for Hyperthermic Oncology, ESHO, Verona, Italy, June 2009.
  74. E. D. Hager, H. Dziambor, D. Höhmann, D. Gallenbeck, M. Stephan, and C. Popa, “Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer,” Anticancer Research, vol. 19, no. 4 C, pp. 3403–3408, 1999. View at Google Scholar · View at Scopus
  75. P. Panagiotou, M. Sosada, S. Schering, and H. Kirchner, “Irinotecan plus Capecitabine with regional electrohyperthermia of the liver as second line therapy in patients with metastatic colorectal cancer,” in Proceedings of the European Society for Hyperthermic Oncology, Graz, Austria, June 2005.
  76. V. D. Ferrari, S. De Ponti, F. Valcamonico et al., “Deep electro-hyperthermia (EHY) with or without thermo-active agents in patients with advanced hepatic cell carcinoma: phase II study,” Journal of Clinical Oncology, vol. 25, Article ID 15168, p. 18S, 2007. View at Google Scholar
  77. G. Fiorentini, M. De Simone, G. Turriti et al., “Deep electro-hyperthermia with radiofrequencies combined with thermoactive drugs in patients with liver metastases from colorectal cancer (CRC): a phase II clinical study,” in Proceedings of the 17th International Congress on Targeted Anticancer Therapies (ICACT '12), Paris, France, 2006.
  78. A. Dani, A. Varkonyi, I. Nyiro, and M. Osvath, “Clinical experience of electro-hyperthermia for advanced pancreatic tumors,” in Proceedings of the Conference of European Society of Hyperthermic Oncology, ESHO, Munich, Germany, June 2003.
  79. F. Douwes, “Thermo-Chemotherapie des fortgeschrittenen Pankreaskarzinoms,” Ergebnisse einer klinischen Anwendungsstudie, 2004, http://kstg.net/publikationen/pdf/thermo-chemotherapie_des_fortgeschrittenen_pankreaskarzinoms.html.
  80. F. R. Douwes, “Thermochemotherapy of the advanced pancreas carcinoma,” Biologische Medizin, vol. 35, pp. 126–130, 2006. View at Google Scholar
  81. A. Dani, A. Varkonyi, T. Magyar, and A. Szasz, “Clinical study for advanced pancreas cancer treated by oncothermia,” Forum Hyperthermie, pp. 13–19, 2008. View at Google Scholar
  82. H. Renner and I. Albrecht, “Analyse der uberlebenszeiten von patienten mit pankreastumoren mit erfolgter kapazitativer hyperthermiebehandlung,” Internal Report of Praxis in Klinikum Nord, Nurnberg, Germany, 2007, Prepared by F. Mirko, May 2007. View at Google Scholar
  83. C. Pang, “Clinical research on integrative treatment of colon carcinoma with oncothermia and clifford tcm immune booster,” Oncothermia Journal, vol. 5, pp. 24–41, 2012. View at Google Scholar
  84. C. Pang, “Clinical research on integrative treatment of colon carcinoma with oncothermia and clifford TCM immune booster,” in Proceedings of the International Oncothermia Symposium, Cologne, Germany, November 2010.
  85. Z. Vigvary, E. Mako, and M. Dank, “Combined radiological and interventional treatment of non-operable rectal tumors and their liver metastases,” in Proceedings of the Regional Radiology Conference, Maribor, Slovenia, September 2002.
  86. A. Szasz, “Oncothermia from laboratory to Clinical practice,” in Proceedings of the 25th Annual Meeting of Korean Gynaecologic Oncology Group, Jeju, Korea, April 2010.
  87. G. Fiorentini, F. Montagnanai, M. Vaira, and M. DeSimone, “Intraperitoneal cisplatine and paclitaxel combined with external capacitive hyperthermia in patients with relapsed epithelial ovarian cancer : a phase II clinical study,” in Proceedings of the International Oncothermia Symposium, Cologne, Germany, November 2010, http://www.io-symposium.com/oncothermia/2010/pres/Fiorentini2.PDF.
  88. A. Szasz, O. Szasz, and N. Szasz, “Electro-hyperthermia: a new paradigm in cancer therapy,” Deutsche Zeitschrift für Onkologie, vol. 33, no. 3, pp. 91–99, 2001. View at Publisher · View at Google Scholar · View at Scopus
  89. A. Szasz, G. Vincze, O. Szasz, and N. Szasz, “An energy analysis of extracellular hyperthermia,” Electromagnetic Biology and Medicine, vol. 22, no. 2-3, pp. 103–115, 2003. View at Publisher · View at Google Scholar · View at Scopus
  90. G. Andocs, H. Renner, L. Balogh, L. Fonyad, C. Jakab, and A. Szasz, “Strong synergy of heat and modulated electromagnetic field in tumor cell killing,” Strahlentherapie und Onkologie, vol. 185, no. 2, pp. 120–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. A. Szasz, N. Szasz, and O. Szasz, Oncothermia: Principles and Practices, Springer, Heidelberg, Germany, 2010.
  92. A. Szasz, “Quo vadis oncologic hyperthermia?” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October2012.
  93. O. Warburg, “The oxigen-transferring ferment of respiration,” Nobel Lecture, December 1931.
  94. U. Mikac, F. Demšar, K. Beravs, and I. Serša, “Magnetic resonance imaging of alternating electric currents,” Magnetic Resonance Imaging, vol. 19, no. 6, pp. 845–856, 2001. View at Publisher · View at Google Scholar · View at Scopus
  95. B. Scholz and R. Anderson, “On electrical impedance scanning-principles and simulations,” Electromedica, vol. 68, pp. 35–44, 2000. View at Google Scholar
  96. L. T. Muftuler, M. J. Hamamura, O. Birgul, and O. Nalcioglu, “In Vivo MRI Electrical Impedance Tomography (MREIT) of tumors,” Technology in Cancer Research and Treatment, vol. 5, no. 4, pp. 381–387, 2006. View at Google Scholar · View at Scopus
  97. M. C. Raff, “Social controls on cell survival and cell death,” Nature, vol. 356, no. 6368, pp. 397–400, 1992. View at Publisher · View at Google Scholar · View at Scopus
  98. R. Damadian, “Tumor detection by nuclear magnetic resonance,” Science, vol. 171, no. 3976, pp. 1151–1153, 1971. View at Google Scholar · View at Scopus
  99. F. W. Cope, “A review of the applications of solid state physics concepts to biological systems,” Journal of Biological Physics, vol. 3, no. 1, pp. 1–41, 1975. View at Publisher · View at Google Scholar · View at Scopus
  100. C. F. Hazlewood, B. L. Nichols, and N. F. Chamberlain, “Evidence for the existence of a minimum of two phases of ordered water in skeletal muscle,” Nature, vol. 222, no. 5195, pp. 747–750, 1969. View at Publisher · View at Google Scholar · View at Scopus
  101. C. F. Hazelwood, D. C. Chang, D. Medina, G. Cleveland, and B. L. Nichols, “Distinction between the preneoplastic and neoplastic state of murine mammary glands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 69, no. 6, pp. 1478–1480, 1972. View at Google Scholar · View at Scopus
  102. A. Szent-Györgyi, “The living state and cancer,” Physiological Chemistry and Physics, vol. 12, no. 2, pp. 99–110, 1980. View at Google Scholar · View at Scopus
  103. A. Szentgyorgyi, Bioelectronics, A Study on Cellular Regulations, Defense and Cancer, Academic Press, New York, NY, USA, 1968.
  104. A. Szentgyorgyi, Electronic Biology and Cancer, Marcel Dekkerm, New York, NY, USA, 1998.
  105. A. A. Marino, I. G. Iliev, M. A. Schwalke, E. Gonzalez, K. C. Marler, and C. A. Flanagan, “Association between cell membrane potential and breast cancer,” Tumor Biology, vol. 15, no. 2, pp. 82–89, 1994. View at Google Scholar · View at Scopus
  106. J. C. Cure, “On the electrical charateristics of cancer. II,” in Proceedings of the International Congress of Electrochemical Treatment of Cancer, Jupiter, Fla, USA, 1995.
  107. E. Revici, Research in Pathophysiology as Basis Guided Chemotherapy, with Special Application to Cancer, D. Van Nostrand, Princeton, NJ, USA, 1961.
  108. G. Fiorentini, C. Milandri, P. Dentico, P. Giordani, V. Catalano, and F. Bunkeila, “Deep electro-hyperthermia with radiofrequencies combined with thermoactive drugs in patients with liver metastases form colorectal cancer (CRC) a phase II clinical study,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  109. Y. Lee, “Outcome analysis and case reports of cancer patients,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  110. C. L. K. Pang, “Research progress of hyperthermia integrate with TCM in treating cancer,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  111. L. Yimin, “Deep hyperthermia combined with traditional chinese medicine in treating benign diseases in clifford hospital,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  112. H. Renner, “Simultane radiothermotherapie bzw,” in Proceedings of the RadioChemoThermoTherapie, Hyperthermia Symposium, Cologne, Germany, October 2003.
  113. F. R. Douwes and S. Lieberman, “Radiofrequency transurethral hyperthermia and complete androgen blockade: a nonsurgical approach to treating prostate cancer,” Alternative and Complementary Therapies, vol. 8, no. 3, pp. 149–156, 2002. View at Google Scholar · View at Scopus
  114. R. Kleef, “Application of transurethral prostate hyperthermia in benign and malign prostate hyperplasia and chronic prostatitis,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  115. E. Babinszky, “Electrohyperthermia application in asthmatic diseases,,” in Proceedings of the Oncothermia Symposium, St. Istvan University, Godollo, Hungary, August 2001.
  116. H. S. Seojiwon, K. N. Eun, and J. Yiduyeon, “Hyperthermia in the patients with small cell lung cancer,” in Proceedings of the Annual Conference of Korean Oncothermia Study Group, Kagnam Severance Hospital, Yonsei University, Seoul, Korea, November 2012.
  117. Z. O. Lyme, “Disease and oncothermia,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  118. F. R. Douwes, “Transurethral hyperthermia in prostate cancer: a ten year observation study,” in Proceedings of the 31st Conference of International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  119. P. G. Seeger and S. Wolz, Succesful Biological Contol of Cancer, Neuwieder Verlagsgesellschaft, 1990.
  120. J. C. Cure, “Cancer an electrical phenomenon,” Resonant, vol. 1, no. 1, 1991. View at Google Scholar
  121. B. W. E. Nordenstrom, Biologically Closed Electric Circuits: Clinical Experimental and Theoretical Evidence for an Additional Circulatory System, Nordic Medical, Stockholm, Sweden, 1983.
  122. B. W. E. Nordenstrom, Exploring BCEC-Systems, (Biologically Closed Electric Circuits), Nordic Medical, Stockholm, Sweden, 1998.
  123. R. Pekar, “Die Perkutane Galvano-Therapie bei Tumoren- Schwachstrombehandlung von zugänglichen Neoplasmen und ihre vitale,” in Hybridisation in Theorie Und Praxis, W. Maudrich, Berlin, Germany, 1996. View at Google Scholar
  124. R. Pekar, The Percutaneous Bio-Electrical Therapy for Tumors, W. Maudrich, Berlin, Germany, 2002.
  125. Y. Song, “Electrochemical therapy in the treatment of malignant tumors on the body surface,” The European Journal of Surgery, vol. 574, supplement, pp. S41–S43, 1994. View at Google Scholar
  126. K. S. Cole, Membranes, Ions and Impulses, University of California Press, Los Angeles, Calif, USA, 1968.
  127. R. Pethig and D. B. Kell, “The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology,” Physics in Medicine and Biology, vol. 32, no. 8, article no. 001, pp. 933–970, 1987. View at Publisher · View at Google Scholar · View at Scopus
  128. B. E. Pennock and H. P. Schwan, “Further observations on the electrical properties of hemoglobin-bound water,” Journal of Physical Chemistry, vol. 73, no. 8, pp. 2600–2610, 1969. View at Google Scholar · View at Scopus
  129. H. P. Schwan, “Determination of biological impedances,” in Physical Techniques in Biological Research, vol. 6, pp. 323–406, Academic Press, New York, NY, USA, 1963. View at Google Scholar
  130. R. Pethig, “Dielectric properties of biological materials: biophysical and medical application,” IEEE Transactions on Electrical Insulation, vol. EI-19, no. 5, pp. 453–474, 1984. View at Google Scholar · View at Scopus
  131. F. Pliquett and U. Pliquett, “Tissue impedance, measured by pulse deformation,” in Proceedings of the 8th International Conference on Electrical Bio-impedance, T. Lahtinen, Ed., pp. 179–181, University of Kuopio, Finland, July 1992.
  132. H. P. Schwan, “Frequency selective propagation of extracellular electrical stimuli to intracellular compartments,” in Nonlinear Electrodynamics in Biological Systems, W. R. Adey and A. F. Lawrence, Eds., pp. 327–338, Pleanum Press, New York, NY, USA, 1989. View at Google Scholar
  133. R. Pethig, “Dielectric properties of biological materials: biophysical and medical application,” IEEE Transactions on Electrical Insulation, vol. EI-19, no. 5, pp. 453–474, 1984. View at Google Scholar · View at Scopus
  134. F. Barnes and Y. Kwon, “A theoretical study of the effects of RF fields in the vicinity of membranes,” Bioelectromagnetics, vol. 26, no. 2, pp. 118–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
  135. J. T. Groves, S. G. Boxer, and H. M. McConnell, “Electric field-induced reorganization of two-component supported bilayer membranes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 25, pp. 13390–13395, 1997. View at Publisher · View at Google Scholar · View at Scopus
  136. J. T. Groves, S. G. Boxer, and H. M. McConnell, “Electric field-induced critical demixing in lipid bilayer membranes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 3, pp. 935–938, 1998. View at Publisher · View at Google Scholar · View at Scopus
  137. D. I. De Pomerai, A. Dawe, L. Djerbib, J. Allan, G. Brunt, and C. Daniells, “Growth and maturation of the nematode Caenorhabditis elegans following exposure to weak microwave fields,” Enzyme and Microbial Technology, vol. 30, no. 1, pp. 73–79, 2002. View at Publisher · View at Google Scholar · View at Scopus
  138. D. I. De Pomerai, B. Smith, A. Dawe et al., “Microwave radiation can alter protein conformation without bulk heating,” FEBS Letters, vol. 543, no. 1–3, pp. 93–97, 2003. View at Publisher · View at Google Scholar · View at Scopus
  139. M. Zhao, J. V. Forrester, and C. D. Mccaig, “A small, physiological electric field orients cell division,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 9, pp. 4942–4946, 1999. View at Publisher · View at Google Scholar · View at Scopus
  140. E. D. Kirson, Z. Gurvich, R. Schneiderman et al., “Disruption of cancer cell replication by alternating electric fields,” Cancer Research, vol. 64, no. 9, pp. 3288–3295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  141. A. Szasz, G. Andocs, O. Szasz, G. Vincze, T. Koncz, and L. Balogh, “Effects far from equilibrium in electromagnetic heating of tissues,” in Proceedings of the Annual Congress of Bioelectromagnetic Society, BEMS, Davos, Switzerland, June 2009.
  142. T. Kotnik and D. Miklavčič, “Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields,” Bioelectromagnetics, vol. 21, no. 5, pp. 385–394, 2000. View at Google Scholar · View at Scopus
  143. G. Andocs and N. Meggyeshazy, “Experimental oncothermia in nude mice xenograft tumor models,” in Proceedings of the 1st International Oncothermia Symposium, pp. 22–23, Cologne, Germany, November 2010.
  144. G. Andocs, O. Szasz, and A. Szasz, “Oncothermia treatment of cancer: from the laboratory to clinic,” Electromagnetic Biology and Medicine, vol. 28, no. 2, pp. 148–165, 2009. View at Google Scholar
  145. R. W. Adey, “Collective properties of cell membranes,” in Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems, B. Norden and C. Ramel, Eds., pp. 47–77, Oxford University Press, Oxford, UK, 1992. View at Google Scholar
  146. W. R. Adey, “Biological effects of electromagnetic fields,” Journal of Cellular Biochemistry, vol. 51, no. 4, pp. 410–416, 1993. View at Google Scholar · View at Scopus
  147. K. R. Foster and M. H. Repacholi, “Biological effects of radiofrequency fields: does modulation matter?” Radiation Research, vol. 162, no. 2, pp. 219–225, 2004. View at Publisher · View at Google Scholar · View at Scopus
  148. C. F. Blackman, “Treating cancer with amplitude-modulated electromagnetic fields: a potential paradigm shift, again?” British Journal of Cancer, vol. 106, pp. 241–242, 2012. View at Publisher · View at Google Scholar
  149. A. Barbault, F. P. Costa, B. Bottger et al., “Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach,” Journal of Experimental and Clinical Cancer Research, vol. 28, no. 1, pp. 51–61, 2009. View at Publisher · View at Google Scholar · View at Scopus
  150. Z. W. Zimmerman, M. J. Pennison, I. Brezovich et al., “Cancer cell proliferation is inhibited by specific modulation frequencies,” British Journal of Cancer, vol. 106, pp. 307–313, 2012. View at Google Scholar
  151. C. F. Blackman, J. A. Elder, C. M. Weil, S. G. Benane, D. C. Eichinger, and D. E. House, “Induction of calcium-ion efflux from brain tissue by radio-frequency radiation: effects of modulation frequency and field strength,” Radio Science, vol. 14, no. 6 S, pp. 93–98, 1979. View at Google Scholar · View at Scopus
  152. C. F. Blackman, “Evidence for disruption by the modulating signal,” BioInitiative Report: A Rationale for a BiologicAlly-Based Public Exposure Standard for Electromagnetic Fields (ELF And RF) Section 14, 2007. View at Google Scholar
  153. F. P. Costa, A. C. deOliveira, R. Meirelles et al., “Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields,” British Journal of Cancer, vol. 105, pp. 640–648, 2011. View at Publisher · View at Google Scholar
  154. D. Rakovic and D. Djordjevic, “Wear amplitude modulated RF EM fields for cancer treatment,” Medical Review, vol. 4, no. 1, pp. 089–092, 2012. View at Google Scholar
  155. B. L. Franzen, “Fractal analysis of microscopic images of breast tissue,” http://www.wseas.us/e-library/conferences/digest2003/papers/466-198.pdf.
  156. M. Tambasco and A. M. Magliocco, “Relationship between tumor grade and computed architectural complexity in breast cancer specimens,” Human Pathology, vol. 39, no. 5, pp. 740–746, 2008. View at Publisher · View at Google Scholar · View at Scopus
  157. A. Delides, I. Panayiotides, A. Alegakis et al., “Fractal dimension as a prognostic factor for laryngeal carcinoma,” Anticancer Research, vol. 25, no. 3 B, pp. 2141–2144, 2005. View at Google Scholar · View at Scopus
  158. J. Walleczek, Ed., Self-Organized Biological Dynamics & Nonlinear Control, Cambridge University Press, Cambridge, UK, 2000.
  159. T. Musha and Y. Sawada, Eds., Physics of the Living State, IOS Press, Amsterdam, The Netherlands, 1994.
  160. B. J. West, Fractal Physiology and Chaos in Medicine, World Scientific, London, UK, 1990.
  161. J. B. Bassingthwaighte, L. S. Leibovitch, and B. J. West, Fractal Physiology, Oxford University Press, New York, NY, USA, 1994.
  162. G. B. West, J. H. Brown, and B. J. Enquist, “The fourth dimension of life: fractal geometry and allometric scaling of organisms,” Science, vol. 284, no. 5420, pp. 1677–1679, 1999. View at Publisher · View at Google Scholar · View at Scopus
  163. J. H. Brown and G. B. West, Eds., Scaling in Biology, Oxford University Press, New York, NY, USA, 2000.
  164. W. A. Calder, Size, Function and Life History, Dover Publications, New York, NY, USA, 1996.
  165. G. Hegyi, G. Vincze, and A. Szasz, “On the dynamic equilibrium in homeostasis,” Open Journal of Biophysics, vol. 2, pp. 64–71, 2012. View at Google Scholar
  166. N. Meggyeshazi, G. Andocs, and T. Krenacs, “Programmed cell death induced by modulated electro-hyperthermia,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  167. G. Andocs, Y. Okamoto, T. Osaki et al., “Proceedings of the Oncothermia research at preclinical level,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October2012.
  168. C. S. Kovago, “Proposed investigation on the possible synergic effect between high dose ascorbic acid application and oncothermia treatment,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  169. G. Fiorentini, P. Dentico, G. Turrisi, and C. Milandri, “Phase II. Clinical study on relapsed malignant gliomas treated with electro-hyperthermia,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  170. W. Qin, Y. Akutsu, Y. Tamura et al., “A novel dendritic cell therapy with oncothermotherapy mediated by abscopal effect,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  171. T. S. Jeoung, “Cases that respond to oncothermia monotherapy,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), pp. 12–14, Budapest, Hungary, October 2012.
  172. M. Ballerini, G. H. Baronzio, O. Szasz, and V. Cassutti, “AndroTherm application for Peyrinie disease (Phase I/II study). Additional seven cases,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  173. S. G. Min, “A case of clinically complete remission of lung with hyperthermia and concurrent 5th-line chemotherapy in a dissaminated NSCLS patient,” in Proceedings of the 31st Conference of the International Clinical Hyperthermia Society (ICHS '12), Budapest, Hungary, October 2012.
  174. A. Dani, A. Varkonyi, T. Magyar, and A. Szasz, “A retrospective study of 1180 cancer patients treated by oncothermia,” Forum Hyperthermia. In press.
  175. A. Szasz, “Clinical studies evidences of modulated rf-conductive heating (mEHT) method,” in Proceedings of the 25th Annual Meeting of the European Society for Hyperthermic Oncology, ESHO, Verona, Italy, June 2009.
  176. A. Szasz, N. Iluri, and O. Szasz, Oncothermia-to Choose or Not to Choose?Oncotherm Group, Páty, Hungary, 2012.