Table of Contents
Conference Papers in Medicine
Volume 2013, Article ID 162831, 4 pages
Conference Paper

How to Use High-Sensitivity Cardiac Troponins in Acute Cardiac Care?

1Department of Cardiology, Angiology and Pneumonology, University Hospital Heidelberg, 69120 Heidelberg, Germany
2Department of Cardiology Campus Virchow Klinikum (CVK) and Division of Emergency Medicine CVK and Campus Charité Mitte (CCM), Charité-University Medicine Berlin, 13353 Berlin, Germany

Received 17 January 2013; Accepted 22 April 2013

Academic Editors: A. Bellou, C. Hamm, and M. Möckel

This Conference Paper is based on a presentation given by H. Katus at “Clinical Decisions in Acute Patients: ACS–POCT–Hypertension and Biomarkers” held from 19 October 2012 to 20 October 2012 in Berlin, Germany.

Copyright © 2013 H. Katus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High-sensitivity troponin assays, when used and viewed in the clinical context, provide a definite diagnostic benefit compared to conventional troponin assays, especially due to the improved early rule-out of acute myocardial infarction in troponin-negative patients. The interpretation of positive troponin results and, thus, the rule-in of acute myocardial infarction have become more challenging. High sensitivity Tn assays can detect very small but prognostically significant troponin increases, but the underlying diagnoses are diverse. Especially patients with non-ACS-related troponin elevations have an adverse outcome and require careful patient management. Additionally, the interpretation of a significant rise or fall of troponin values has not been standardized yet. Despite these challenges, troponin is a unique marker, which allows for the specific detection of myocardial cell necrosis and the new high sensitivity assays are a great chance to identify more patients at risk and improve their management and care.