Critical Analysis of Electromagnetic Hyperthermia Randomized Trials: Dubious Effect and Multiple Biases

Table 7

Comparison of clinical results of TRT trials with best results of only RT trials for cervical cancer.

Trial	van der Zee et al., 2000, 2002, and 2008 [21, 25, 26]		Harima et al., 2001 [24]		Vasanthan et al., 2005 [15]		Perez et al., 1998, 1995 [14, 31]	Ito et al., 1994 [30]	Barillot et al., 1997 [32]		Fletcher, 1968 [33]
Stage	TRT	RT	TRT	RT	TRT	RT	RT	RT	RT		RT
Parameter	IIIB (IIB–IVA)		IIIB		IIIB (IIB–IVA)		III	III	IIIA	IIIB	IIIA	IIIB
CLR	83%	57%	80%	50%	80%			80%
3 y LDFS	61%	41%	80%	49%	68.5%
3 y OS	51%	27%	58%	48%	73.2%
5 y LDFS	61%	37%							65%	59%
5 y OS	41%	23%						47%	69%	48%	45%	36%
10 y LDFS	61%	37%					68%
10 y OS	37%	20%					45%				36%	30%

CLR: complete local response, LDFS: local disease-free survival, and OS: overall survival.