Table of Contents
Conference Papers in Medicine
Volume 2013 (2013), Article ID 718031, 8 pages
http://dx.doi.org/10.1155/2013/718031
Conference Paper

Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation

1Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
2Yale University School of Medicine, New Haven, CT, USA
3SIEP-The Society for the Investigation of Early Pregnancy, 1697 Lark Lane, Cherry Hill, NJ 08003, USA
4BioIncept, LLC, Cherry Hill, NJ 08003, USA
5Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

Received 4 April 2013; Accepted 12 May 2013

Academic Editors: H.-D. Volk and A. Yussim

This Conference Paper is based on a presentation given by Reut Shainer at “International Conference on New Trends in Immunosuppression and Immunotherapy 2013” held from 11 March 2013 to 12 March 2013 in Barcelona, Spain.

Copyright © 2013 Reut Shainer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bone marrow transplantation (BMT), a well-established treatment for hematological diseases, is frequently hampered by graft-versus-host disease (GVHD) and/or by infections due to delay in immune restoration. Prelmplantation Factor (PIF) is an embryo-derived peptide whose physiological function is to regulate local and systemic immunity and promote transplant acceptance. Synthetic PIF’s effectiveness to regulate immune response following BMT was herein examined in murine model. PIF administration reduced GVHD following allogenic BMT, decreased skin, liver, and colon inflammation and down regulated GVHD-associated gene expression in the liver. iNOS gene expression was reduced both in liver and colon. In syngeneic BMT, PIF administration reduced proinflammatory genes expression and promoted mice weight recovery up to two months after transplantation. PIF immune-regulatory effects were mediated via interaction with monocytes, resulting in decreased iNOS expression and NO secretion in-vitro. Overall, we demonstrate that by regulating immune response after BMT, PIF reduces inflammation and oxidative stress, leading to transplant success.