Table of Contents
Conference Papers in Medicine
Volume 2013, Article ID 879513, 4 pages
Conference Paper

Hyperfractionated Thermoradiotherapy Is More Effective and Less Invasive Than Radiation or Chemoradiation in Heatable Cancers: A Meta-Analysis

Bicher Cancer Institute, 12099 W. Washington Boulevard, Los Angeles, CA 90066, USA

Received 24 January 2013; Accepted 8 July 2013

Academic Editors: G. Baronzio, M. Jackson, D. Y. Lee, and A. Szasz

This Conference Paper is based on a presentation given by Haim I. Bicher at “Conference of the International Clinical Hyperthermia Society 2012” held from 12 October 2012 to 14 October 2012 in Budapest, Hungary.

Copyright © 2013 Haim I. Bicher. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


HTRT consists of daily hyperthermia treatments in conjunction with each radiation fraction. Radiation daily doses are progressively decreased from 180 to 100 cGy resulting in protracted treatment time that decreases the isoeffect biological equivalent dose by 15% to 25%. This decrease is compensated by the increased number of hyperthermia fractions which potentiates each radiation dose. Treatment is continued until an objective complete response is attained, or failure determined. Sixty breast patients, 35 head and neck, and 25 prostate patients were treated with a followup of two to five years. All patients were early stage (less than III). HTRT proved to be less toxic and more effective than radiation or chemoradiation therapies.