Table of Contents
Conference Papers in Medicine
Volume 2013, Article ID 928243, 5 pages
Conference Paper

Autoregulation of the Brain Temperature during Whole Body Hyperthermia

1Bicher Cancer Institute, 12099 W Washington Boulevard, No. 304, Los Angeles, CA 90066, USA
2I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0160 Tbilisi, Georgia

Received 14 January 2013; Accepted 17 April 2013

Academic Editors: G. F. Baronzio, M. Jackson, and A. Szasz

This Conference Paper is based on a presentation given by Nodar Mitagvaria at “Conference of the International Clinical Hyperthermia Society 2012” held from 12 October 2012 to 14 October 2012 in Budapest, Hungary.

Copyright © 2013 Haim I. Bicher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was revealing the temperature changes in rats' brain tissue caused by whole body hyperthermia. The analysis of received results allows to conclude that the brain has a highly secured system of temperature autoregulation against the exogenous temperature changes. The upper limit of this autoregulation (for rats, at least) is in the range of 45°C of environment. An important role in the normal functioning of the brain temperature autoregulation system belongs to Nitric Oxide. The behavioral disorders, observed in animals after whole body hyperthermia (sure within the range of brain temperature autoregulation) are hardly associated with the changes in temperature of the Central Nervous System, but rather have to be mediated by impaired blood circulation and oxygen supply to the brain tissues, caused by the rapid deterioration of the blood rheological properties.