Table of Contents
Conference Papers in Science
Volume 2014, Article ID 304974, 6 pages
http://dx.doi.org/10.1155/2014/304974
Conference Paper

Travelling along the Clinical Roadmap: Developing Electrospun Scaffolds for Tendon Repair

School of Materials, The University of Manchester, Oxford Road, Manchester M13 9PL, UK

Received 6 September 2013; Accepted 10 February 2014; Published 23 March 2014

Academic Editors: J. Gough, R. Sammons, and C. Scotchford

This Conference Paper is based on a presentation given by Lucy A. Bosworth at “UK Society for Biomaterials Annual Conference 2013” held from 24 June 2013 to 25 June 2013 in Birmingham, United Kingdom.

Copyright © 2014 Lucy A. Bosworth. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Biopolymers, such as poly(ε-caprolactone), can be easily electrospun to create fibrous scaffolds. It is also possible to control the alignment of the emitted fibres and further manipulate these scaffolds to create 3D yarn structures, which resemble part of the tendon tissue hierarchy. Material properties, such as tensile strength, can be tailored depending on the selection and combination of polymer and solvent used during electrospinning. The scaffolds have been proven to separately support the adhesion and proliferation of equine tendon fibroblasts and human mesenchymal stem cells whilst simultaneously directing cell orientation, which caused their alignment parallel to the underlying fibres. Implantation of scaffolds into the flexor digitorum profundus tendon of mice hindpaws yielded encouraging results with minimal inflammatory reaction and observation of cell infiltration into the scaffold. This research demonstrates the progression of electrospun fibres along the clinical roadmap towards becoming a future medical device for the treatment of tendon injuries.