Use of Poly (𝜺-Lysine) Dendrons: A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation

Table 1

Treatments used against cultures of Pseudomonas  aeruginosa.

Treatment	Comments
RGnK*	Equimolar final concentration of NH2 outermost groups, where RG1K was applied at 1600 𝜇M, RG2K at 800 𝜇M, and RG3K 400 𝜇M.
Ciprofloxacin	Minimal inhibitory concentration of 0.5 𝜇g/mL.
Administration of RGnK followed by ciprofloxacin (0.5 𝜇g/mL)	Dendron: equimolar final concentration of NH2 outermost groups, where RG1K was applied at 1600 𝜇M, RG2K at 800 𝜇M, and RG3K 400 𝜇M. Ciprofloxacin: MIC of 0.5 𝜇g/mL.
Coadministration of RGnK and ciprofloxacin (0.5 𝜇g/mL)	Dendron: equimolar final concentration of NH2 outermost groups, where RG1K was applied at 1600 𝜇M, RG2K at 800 𝜇M, and RG3K 400 𝜇M. Ciprofloxacin: MIC of 0.5 𝜇g/mL.
Positive growth control	Only cells.
Negative growth control	Only medium (NB).

∗RGnK: branching generation number (𝑛) of a poly (𝜀-lysine) dendron with an arginine residue.