Table of Contents
Conference Papers in Science
Volume 2014, Article ID 684352, 7 pages
http://dx.doi.org/10.1155/2014/684352
Conference Paper

Antibacterial Activity of a Chitosan-PVA-Ag+-Tobermorite Composite for Periodontal Repair

School of Science, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK

Received 21 November 2013; Accepted 12 February 2014; Published 7 April 2014

Academic Editors: J. Gough and R. Sammons

This Conference Paper is based on a presentation given by Andrew P. Hurt at “UK Society for Biomaterials Annual Conference 2013” held from 24 June 2013 to 25 June 2013 in Birmingham, United Kingdom.

Copyright © 2014 Andrew P. Hurt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A polymer-mineral composite was prepared by solvent casting a mixture of chitosan, poly(vinyl alcohol), and Ag+-exchanged tobermorite in dilute acetic acid and characterised by scanning electron microscopy and Fourier transform infrared spectroscopy. The in vitro bioactivity of the CPTAg membrane was confirmed by the formation of hydroxyapatite on its surface in simulated body fluid. The alkaline dissolution products of the tobermorite lattice buffered the acidic breakdown products of the chitosan polymer and the presence of silver ions resulted in marked antimicrobial action against S. aureus, P. aeruginosa, and E. coli. The in vitro cytocompatibility of the CPTAg membrane was confirmed using MG63 osteosarcoma cells. The findings of this preliminary study have indicated that chitosan-poly(vinyl alcohol)-Ag+-tobermorite composites may be suitable materials for guided tissue regeneration applications.