Table of Contents
Conference Papers in Science
Volume 2015, Article ID 593086, 9 pages
Conference Paper

Local Angiotensin Pathways in Human Carotid Atheroma: Towards a Systems Biology Approach

1EA4173-Functional Genomics in Hypertension, Université de Lyon, Hôpital Nord-Ouest, Villefranche, Lyon, France
2Service de Pharmacologie, INSERM U1088, Centre de Biologie Humaine, CHU Amiens, avenue Laennec, Salouel, 80000 Amiens, France

Received 19 June 2014; Revised 21 December 2014; Accepted 30 December 2014

Academic Editor: Antonio Lepedda

This Conference Paper is based on a presentation given by Giampiero Bricca at “LIAC Meeting on Vascular Research 2013” held from 18 September 2013 to 21 September 2013 in Alghero, Italy.

Copyright © 2015 Giampiero Bricca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We will summarize the data we have obtained in human carotid artery concerning the organization of an extended local renin angiotensin aldosterone system and its variations at different stages of atheroma. In a system view, we propose a model where concomitant increase in angiotensin and glucocorticoid signaling is induced and amplified in VSMC while vascular smooth muscle cells transdifferentiate toward a lipid storing phenotype.