Local Angiotensin Pathways in Human Carotid Atheroma: Towards a Systems Biology Approach

Figure 2

Extended RAAS. (a) The peptidases able to perform Ang II synthesis and the peptidases involved in the generation of the other potential active peptides Ang 1–7 and Ang IV have been added to the classical RAAS system, a schematic bradykinin pathway including kininogen, the bradykinins receptors B1 and B2. The gluco- and mineralocorticoids signaling comprises enzymes and receptors. (b) The cortico- and mineralocorticoid pathways components. Although the number of metabolites is high, the number of enzymes and receptors is rather limited. 39 potential contributors to any tissue extended RAAS taking into account kinin precursor and receptors and a complete gluco/mineralocorticoid pathways were considered. Adapted from KEGG database: http://genome.jp/kegg/pathway/map/map00140.html.

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