Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009 (2009), Article ID 107286, 9 pages
http://dx.doi.org/10.1155/2009/107286
Research Article

Role of Hypertension in Aggravating A Neuropathology of AD Type and Tau-MediatedMotor Impairment

1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY10029, USA
2Alzheimer Disease Research Unit, CIEN Foundation-Reina Sofia Foundation, Valderrebollo 5, 28031 Madrid, Spain
3GRECC, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA

Received 8 April 2009; Revised 19 June 2009; Accepted 2 July 2009

Academic Editor: Christian Humpel

Copyright © 2009 C. Díaz-Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epidemiological evidence suggests that hypertension may accelerate the onset and progression of Alzheimer's disease (AD). In this study, we explored the role of hypertension in the neurodegenerative changes associated with A and tau aggregation. We induced hypertension in Tg2576 and P301L-tauTg mouse models. In Tg2576 mice, experimental hypertension was associated with a significant increase of the accumulation of Amyloid- (A ) peptides in brain tissue and a significant reduction of A peptides in serum . These results indicate that hypertension may promote AD-type A neuropathology in Tg2576. In P301L-tauTg mice we found that the presence of hypertension was significantly associated with aggravated motor function assessed by hindlimb extension test . These results suggest that hypertension may play a role in accelerating the progression of motor dysfunction associated with tau-related alterations. Our studies suggest that the management of blood pressure (BP) may alleviate AD-type A neuropathology and neurological disorders associated with abnormal tau metabolism.