Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2009, Article ID 174657, 5 pages
http://dx.doi.org/10.1155/2009/174657
Hypothesis

The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging

Department of Pharmacology School of Medicine, Temple University, Philadelphia, PA 19140, USA

Received 19 May 2009; Accepted 29 June 2009

Academic Editor: Hari Manev

Copyright © 2009 Jin Chu and Domenico Praticò. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Najjar, A. Scuteri, and E. G. Lakatta, “Arterial aging: is it an immutable cardiovascular risk factor?” Hypertension, vol. 46, no. 3, pp. 454–462, 2005. View at Publisher · View at Google Scholar · View at PubMed
  2. M. Goedert and M. G. Spillantini, “A century of Alzheimer's disease,” Science, vol. 314, no. 5800, pp. 777–781, 2006. View at Publisher · View at Google Scholar · View at PubMed
  3. X. Zhang, R. Qi, X. Xian et al., “Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet,” Circulation Research, vol. 102, no. 2, pp. 250–256, 2008. View at Publisher · View at Google Scholar · View at PubMed
  4. M. A. Lynch, “Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1β?” Progress in Neurobiology, vol. 56, no. 5, pp. 571–589, 1998. View at Publisher · View at Google Scholar
  5. K. Sugaya, M. Chouinard, R. Greene et al., “Molecular indices of neuronal and glial plasticity in the hippocampal formation in a rodent model of age-induced spatial learning impairment,” Journal of Neuroscience, vol. 16, no. 10, pp. 3427–3443, 1996. View at Google Scholar
  6. A. R. Brash, “Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate,” Journal of Biological Chemistry, vol. 274, no. 34, pp. 23679–23682, 1999. View at Publisher · View at Google Scholar
  7. Y. Zou, D. H. Kim, K. J. Jung et al., “Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging,” Rejuvenation Research, vol. 12, no. 1, pp. 15–24, 2009. View at Publisher · View at Google Scholar · View at PubMed
  8. C.-H. Lammers, P. Schweitzer, P. Facchinetti et al., “Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling,” Journal of Neurochemistry, vol. 66, no. 1, pp. 147–152, 1996. View at Google Scholar
  9. C. M. Chinnici, Y. Yao, and D. Praticò, “The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old,” Neurobiology of Aging, vol. 28, no. 9, pp. 1457–1462, 2007. View at Publisher · View at Google Scholar · View at PubMed
  10. T. Uz, P. Longone, and H. Manev, “Increased hippocampal 5-lipoxygenase mRNA content in melatonin-deficient, pinealectomized rats,” Journal of Neurochemistry, vol. 69, no. 5, pp. 2220–2223, 1997. View at Google Scholar
  11. T. Uz, Y. Dwivedi, A. Qeli, M. Peters-Golden, G. Pandey, and H. Manev, “Glucocorticoid receptors are required for up-regulation of neuronal 5-lipoxygenase (5-LOX) expression by dexamethasone,” The FASEB Journal, vol. 15, no. 10, pp. 1792–1794, 2001. View at Google Scholar
  12. F. Magri, M. Locatelli, G. Balza et al., “Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging,” Chronobiology International, vol. 14, no. 4, pp. 385–396, 1997. View at Google Scholar
  13. M. G. Frank, M. V. Baratta, D. B. Sprunger, L. R. Watkins, and S. F. Maier, “Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses,” Brain, Behavior, and Immunity, vol. 21, no. 1, pp. 47–59, 2007. View at Publisher · View at Google Scholar · View at PubMed
  14. M. Mehrabian, H. Allayee, J. Wong et al., “Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice,” Circulation Research, vol. 91, no. 2, pp. 120–126, 2002. View at Publisher · View at Google Scholar
  15. J. H. Dwyer, H. Allayee, K. M. Dwyer et al., “Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis,” New England Journal of Medicine, vol. 350, no. 1, pp. 29–37, 2004. View at Publisher · View at Google Scholar · View at PubMed
  16. A. Helgadottir, A. Manolescu, G. Thorleifsson et al., “The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke,” Nature Genetics, vol. 36, no. 3, pp. 233–239, 2004. View at Publisher · View at Google Scholar · View at PubMed
  17. K. W. Weingand, T. B. Clarkson, M. R. Adams, and A. D. Bostrom, “Effects of age and/or puberty on coronary artery atherosclerosis in cynomolgus monkeys,” Atherosclerosis, vol. 62, no. 2, pp. 137–144, 1986. View at Google Scholar
  18. L. G. Spagnoli, A. Orlandi, A. Mauriello et al., “Aging and atherosclerosis in the rabbit. 1. Distribution, prevalence and mosphology of atherosclerotic lesions,” Atherosclerosis, vol. 89, no. 1, pp. 11–24, 1991. View at Google Scholar
  19. J. E. Mcewen, P. Zimniak, J. L. Mehta, and R. J. Shookler Reis, “Molecular pathology of aging and its implications for senescent coronary atherosclerosis,” Current Opinion in Cardiology, vol. 20, no. 5, pp. 399–406, 2005. View at Publisher · View at Google Scholar
  20. N. R. Madamanchi and M. S. Runge, “Mitochondrial dysfunction in atherosclerosis,” Circulation Research, vol. 100, no. 4, pp. 460–473, 2007. View at Publisher · View at Google Scholar · View at PubMed
  21. A. Csiszar, N. Labinskyy, X. Zhao et al., “Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity,” Aging Cell, vol. 6, pp. 783–797, 2007. View at Google Scholar
  22. E. Lalla, I. B. Lamster, M. A. Hofman et al., “Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, pp. 1405–1411, 2003. View at Google Scholar
  23. L. Li, E. L. Batista Jr., R. A. Levine et al., “Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in heterozygous apolipoprotein E-deficient murine model,” Circulation, vol. 105, pp. 861–867, 2002. View at Google Scholar
  24. D. Recalde, M. A. Ostos, E. Badell et al., “Human apolipoprotein A-IV reduces secretion of proinflammatory cytokines and atherosclerotic effects of a chronic infection mimicked by lipopolysaccharides,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, pp. 756–761, 2004. View at Google Scholar
  25. K. J. Serio, K. V. Reddy, and T. D. Bigby, “Lipopolysaccharide induces 5-lipoxygenase-activating protein gene expression in THP-1 cells via a NF-κB and C/EBP-mediated mechanism,” American Journal of Physiology, vol. 288, no. 5, pp. C1125–C1133, 2005. View at Publisher · View at Google Scholar · View at PubMed
  26. M. Collin, A. Rossi, S. Cuzzocrea et al., “Reduction of the multiple organ injury and dysfunction caused by endotoxinemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton,” Journal of Leukocyte Biology, vol. 76, pp. 961–970, 2004. View at Google Scholar
  27. P. L. McGeer and E. G. McGeer, “Inflammation and the degenerative diseases of aging,” Annals of the New York Academy of Sciences, vol. 1035, pp. 104–116, 2004. View at Publisher · View at Google Scholar · View at PubMed
  28. D. Praticò, “Alzheimer's disease and oxygen radicals: new insights,” Biochemical Pharmacology, vol. 63, no. 4, pp. 563–567, 2002. View at Publisher · View at Google Scholar
  29. T. B. L. Kirkwood, M. Feder, C. E. Finch et al., “What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?” Mechanisms of Ageing and Development, vol. 126, no. 3, pp. 439–443, 2005. View at Publisher · View at Google Scholar · View at PubMed
  30. J. Chen, J. B. Buchanan, N. L. Sparkman, J. P. Godbout, G. G. Freund, and R. W. Johnson, “Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system,” Brain, Behavior, and Immunity, vol. 22, no. 3, pp. 301–311, 2008. View at Publisher · View at Google Scholar · View at PubMed
  31. J. P. Godbout, J. Chen, J. Abraham, A. F. Richwine, B. M. Berg, K. W. Kelley, and R. W. Johnson, “Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system,” FASEB Journal, vol. 19, no. 10, pp. 1329–1331, 2005. View at Publisher · View at Google Scholar · View at PubMed
  32. G. Riccioni, C. Di Ilio, P. Conti, T. C. Theoharides, and N. D'Orazio, “Advances in therapy with antileukotriene drugs,” Annals of Clinical and Laboratory Science, vol. 34, no. 4, pp. 379–387, 2004. View at Google Scholar
  33. M. I. Combrinck, V. H. Perry, and C. Cunningham, “Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease,” Neuroscience, vol. 112, no. 1, pp. 7–11, 2002. View at Publisher · View at Google Scholar
  34. M. Imbesi, I. Zavoreo, T. Uz et al., “5-lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo,” Brain Research, vol. 1147, no. 1, pp. 148–153, 2007. View at Publisher · View at Google Scholar · View at PubMed
  35. O. Firuzi, J. Zhuo, C. M. Chinnici, T. Wisniewski, and D. Praticò, “5-lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease,” FASEB Journal, vol. 22, no. 4, pp. 1169–1178, 2008. View at Publisher · View at Google Scholar · View at PubMed
  36. J. G. Csernansky, H. Dong, A. M. Fagan et al., “Plasma cortisol and progression of dementia in subjects with Alzheimer's disease-type dementia,” The American Journal of Psychiatry, vol. 163, pp. 2164–2169, 2006. View at Google Scholar
  37. R. S. Wilson, S. E. Arnold, J. A. Schneider, J. F. Kelly, Y. Tang, and D. A. Bennett, “Chronic psychological distress and risk of Alzheimer's disease in old age,” Neuroepidemiology, vol. 27, no. 3, pp. 143–153, 2006. View at Publisher · View at Google Scholar · View at PubMed
  38. C. Cunningham, D. C. Wilcockson, S. Campion, K. Lunnon, and V. H. Perry, “Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration,” Journal of Neuroscience, vol. 25, no. 40, pp. 9275–9284, 2005. View at Publisher · View at Google Scholar · View at PubMed
  39. M. D. Nguyen, T. D’Aigle, G. Gowing, J.-P. Julien, and S. Rivest, “Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis,” Journal of Neuroscience, vol. 24, no. 6, pp. 1340–1349, 2004. View at Publisher · View at Google Scholar · View at PubMed
  40. M. A. Ostos, D. Recalde, M. M. Zakin, and D. Scott-Algara, “Implication of natural killer T cells in atherosclerosis development during LPS-induced chronic inflammation,” FEBS Letters, vol. 519, pp. 23–29, 2002. View at Google Scholar
  41. S. K. Heo, H. J. Yun, E. K. Noh, W. H. Park, and S. D. Park, “LPS induces inflammatory responses in human aortic vascular smooth muscle cells via toll-like receptor 4 expression and nitric oxide production,” Immunology Letters, vol. 120, pp. 57–64, 2008. View at Google Scholar
  42. G. R. Swanwick, M. Kirby, I. Bruce et al., “Hypothalalmic-pituitary-adrenal axis dysfunction in Alzheimer’s disease: lack of association between longitudinal and cross-sectional findings,” The American Journal of Psychiatry, vol. 155, pp. 286–289, 1998. View at Google Scholar
  43. B. Stein-Behrens, M. P. Mattson, I. Chang, M. Yeh, and R. Sapolsky, “Stress exacerbates neuronal loss and cytoskeletal pathology in the hippocampus,” The Journal of Neuroscience, vol. 14, pp. 5373–5380, 1994. View at Google Scholar
  44. P. S. Aisen, K. L. Davis, J. D. Berg et al., “A randomized controlled trial of prednisone in Alzheimer’s disease,” Neurology, vol. 54, pp. 588–593, 2000. View at Google Scholar
  45. J. Nijm and L. Jonasson, “Inflammation and cortisol response in coronary artery disease,” Annals of Internal Medicine, vol. 41, pp. 224–233, 2009. View at Google Scholar
  46. O. Radmark and B. Samulesson, “5-lipoxygenase: regulation and possible involvement in atherosclerosis,” Prostaglandins & Other Lipid Mediators, vol. 83, pp. 162–174, 2007. View at Google Scholar