Review Article
Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease
Figure 2
A model for the roles of activated astrocytes, activated microglia, and S100B in delayed infarct expansion after focal cerebral ischemia. The glial cytokine cycle is represented by dotted lines. Abbreviations used: COX-2: cyclooxygenase-2; : extracellular glutamate; GLAST: glutamate/aspartate transporter; GLT-1: glutamate transporter subtype 1; GSH: glutathione; IL-1: interleukin-1; IL-6: interleukin-6; iNOS: inducible nitric oxide synthase; NF-B: nuclear factor-B; NO: nitric oxide; TNF-: tumor necrosis factor-; RAGE: receptor for advanced glycation endproducts; ROS: reactive oxygen species.
