The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease

<table>Schematic diagram of the three-compartment model of tissue. EES: extravascular extracellular space; EIS: extravascular intracellular space; <svg height="19.075001" id="M50" style="vertical-align:-4.25465pt" version="1.1" viewbox="0 0 21.7125 19.075001" width="21.7125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,19.075)">
<g transform="translate(72,-56.74)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜏</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.55,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="9.1400003">𝑏</tspan>
<tspan style="font-size: 8.75px; " x="0" y="0">−</tspan>
<tspan style="font-size: 8.75px; " x="5.99512" y="0">1</tspan>
</text>
</g>
</g>
</svg>: unidirectional rate constant for water extravasation; <svg height="12.7125" id="M51" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 35.150002 12.7125" width="35.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.7125)">
<g transform="translate(72,-61.83)">
<text transform="matrix(1,0,0,-1,-71.95,61.88)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝐾</tspan>
</text>
<text transform="matrix(1,0,0,-1,-61.42,66.88)">
<tspan style="font-size: 8.75px; " x="0" y="0">t</tspan>
<tspan style="font-size: 8.75px; " x="2.4330561" y="0">r</tspan>
<tspan style="font-size: 8.75px; " x="5.329968" y="0">a</tspan>
<tspan style="font-size: 8.75px; " x="9.2158556" y="0">n</tspan>
<tspan style="font-size: 8.75px; " x="13.591856" y="0">s</tspan>
</text>
</g>
</g>
</svg>: pseudo-first-order rate constant for CR extravasation.</table>

Cardiovascular Psychiatry and Neurology

fig2

Figure 2

Figure 2: The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease 