Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy
Figure 3
The extent of qEEG slowing in PTE patients correlates with BBB disruption. (a) An enlarged region of normalized sLORETA values for the delta band in voxels number 3900–4100 from healthy controls. The entire normalized sLORETA for the delta band is shown in the inset, as are 2 examples of signal localization to the frontal midline region. (b) The PTE population displayed marked variability among the same voxels, and maximal signal localization was varied according to the site of injury. (c) The volume of cortex with abnormal cortical activity according to sLORETA between patients with the bottom (black) and top (white) half volume of BBB disruption or cortical lesion. Note that patients with a larger volume of BBB disruption also had a significantly larger volume of dysfunctional cortex. *= .
