Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats

Table 2

Scatchard analysis of dopamine (D₂) receptor (³H-spiperone) binding activity to striatal membranes of rats in sham, lesion, L+CUR, L+DMC, and L+BDMC.

Parameter	Sham	Lesion	L+Curcumin	L+DMC	L+BDMC
D2 receptor binding assay	300 ± 8.65	660 ± 8.85	405.5 ± 9.39^a	469.2 ± 10.52^a,b	515 ± 8.85^a,b++,c
(pmol ^3H-spriperone bound/gm protein)
Bmax	513.8 ± 10.88	990.7 ± 9.40	598.3 ± 12.22^a	765.8 ± 18.55^a,b	840 ± 16.73^a,b+,c
Kd	0.85 ± 0.01	0.51 ± 0.01	0.89 ± 0.01^a	0.70 ± 0.01^a,b	0.66 ± 0.02^a,c

Bmax: maximum number of binding sites expressed in pmoles bound/g protein; Kd: dissociation constant expressed in nM. Values are in mean ± SEM (𝑛=6). Levels of significance: ^a𝑃≤0.001; ^a+𝑃≤0.01 compared with lesion; ^b𝑃≤0.001; ^b+𝑃≤0.01; ^b++𝑃≤0.05 compared with L+CUR; ^c𝑃≤0.001 and ^c++𝑃≤0.05 compared with L+DMC.