Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database
Table 3
Baseline characteristics at index date of the patients exposed to antipsychotics, psychiatric nonuser cohort, and general population controls.
Characteristic
Exposed to antipsychotics ( = 183,392)
Typical antipsychotics ( = 115,491)
Atypical antipsychotics ( = 67,901)
Psychiatric nonusers ( = 193,920)
General population control ( = 544,726)
Prevalent users
67,396 (36.7%)
40,258 (34.9%)
27,138 (40.0%)
0 (0.0%)
0 (0.0%)
Female
107,226 (58.5%)
69,426 (60.1%)
37,800 (55.7%)
132,458 (68.3%)
317,152 (58.2%)
Male
76,166 (41.5%)
46,065 (39.9%)
30,101 (44.3%)
61,462 (31.7%)
227,574 (41.8%)
Age: mean (sd)
60 (22)
61 (21)
58 (23)
52 (22)
60 (22)
Age: median (IQR)
62 (41–80)
64 (44–80)
58 (38–81)
48 (33–75)
61 (41–80)
Age 18–29
18,474 (10.1%)
9,180 (7.9%)
9,294 (13.7%)
34,559 (17.8%)
55,188 (10.1%)
Age 30–39
23,484 (12.8%)
13,747 (11.9%)
9,737 (14.3%)
38,574 (19.9%)
70,462 (12.9%)
Age 40–49
23,793 (13.0%)
14,554 (12.6%)
9,239 (13.6%)
28,555 (14.7%)
71,370 (13.1%)
Age 50–59
21,244 (11.6%)
14,627 (12.7%)
6,617 (9.7%)
21,302 (11.0%)
63,724 (11.7%)
Age 60–69
19,923 (10.9%)
14,461 (12.5%)
5,462 (8.0%)
13,831 (7.1%)
59,723 (11.0%)
Age 70–79
28,088 (15.3%)
18,881 (16.3%)
9,207 (13.6%)
21,194 (10.9%)
84,519 (15.5%)
Age 80+
48,386 (26.4%)
30,041 (26.0%)
18,345 (27.0%)
35,905 (18.5%)
139,740 (25.7%)
BMI: mean (sd)
26 (6)
26 (5)
26 (6)
26 (6)
26 (5)
Nonsmoker
69,482 (37.9%)
44,035 (38.1%)
25,447 (37.5%)
80,061 (41.3%)
249,362 (45.8%)
Ex-smoker
29,719 (16.2%)
17,638 (15.3%)
12,081 (17.8%)
39,550 (20.4%)
99,240 (18.2%)
Smoker
51,938 (28.3%)
31,361 (27.2%)
20,577 (30.3%)
57,004 (29.4%)
102,455 (18.8%)
Unknown smoking status
32,253 (17.6%)
22,457 (19.4%)
9,796 (14.4%)
17,305 (8.9%)
93,669 (17.2%)
Schizophrenia
15,475 (8.4%)
6,746 (5.8%)
8,729 (12.9%)
7,779 (4.0%)
0 (0.0%)
Bipolar disorder/other mood disorders
7,368 (4.0%)
3,170 (2.7%)
4,198 (6.2%)
4,700 (2.4%)
0 (0.0%)
Major depression
19,981 (10.9%)
11,680 (10.1%)
8,301 (12.2%)
134,105 (69.2%)
0 (0.0%)
Dementia
25,174 (13.7%)
12,669 (11.0%)
12,505 (18.4%)
47,336 (24.4%)
0 (0.0%)
No recorded specific psychiatric disorders
115,394 (62.9%)
81,226 (70.3%)
34,168 (50.3%)
0 (0.0%)
544,726 (100.0%)
History of alcoholism or drug abuse
19,933 (10.9%)
11,429 (9.9%)
8,504 (12.5%)
12,572 (6.5%)
13,256 (2.4%)
History of suicide attempts
10,777 (5.9%)
5,762 (5.0%)
5,015 (7.4%)
8,841 (4.6%)
3,537 (0.6%)
Diabetes mellitus
15,276 (8.3%)
9,480 (8.2%)
5,796 (8.5%)
13,639 (7.0%)
36,069 (6.6%)
Acute myocardial infarction
6,530 (3.6%)
4,224 (3.7%)
2,306 (3.4%)
5,466 (2.8%)
19,391 (3.6%)
Prescribing of statins/fibrates in the 3 months before
