Cardiovascular Psychiatry and Neurology

Clinical Study

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Table 5

RR of all-cause mortality (excluding suicide) and cardiac mortality in exposed cohort, psychiatric nonuser cohort, and general population controls.


Outcome	Exposure	No. of cases	Incidence rate per 1000 person-years	Age, sex-adjusted relative risk (RR) (95% CI)	Fully adjusted RR (aRR) (95% CI)

All-cause mortality	General population	41,546	39.6	Reference	Reference
	Current use	23,841	86.1	2.98 (2.93–3.03)^‡	2.72 (2.67–2.77)^‡
	Psychiatric nonusers	7,765	25.3	Reference	Reference
	Current use	23,841	86.1	2.15 (2.10–2.21)^‡	1.75 (1.64–1.87)^‡

Cardiac mortality	General population	6,532	11.9	Reference	Reference
	Current use	2,478	17.0	2.01 (1.92–2.10)^‡	1.83 (1.74–1.93)^‡
	Psychiatric nonusers	1,289	6.4	Reference	Reference
	Current use	2,478	17.0	1.62 (1.52–1.74)^‡	1.72 (1.42–2.07)^‡

SCD-primary definition	General population	46	0.8	Reference	Reference
	Current use	44	2.7	4.45 (2.94–6.73)^‡	4.03 (2.63–6.16)^‡
	Psychiatric nonusers	10	0.4	Reference	Reference
	Current use	44	2.7	5.76 (2.90–11.45)^‡	5.76 (2.90–11.45)^‡

SCD-secondary definition	General population	244	4.0	Reference	Reference
	Current use	178	11.0	3.48 (2.87–4.23)^‡	2.89 (2.32–3.60)^‡
	Psychiatric nonusers	98	4.1	Reference	Reference
	Current use	178	11.0	2.36 (1.84–3.02)^‡	2.15 (1.64–2.81)^‡

SCD-tertiary definition	General population	370	2.3	Reference	Reference
	Current use	198	4.6	2.47 (2.08–2.94)^‡	2.11 (1.73–2.56)^‡
	Psychiatric nonusers	119	1.8	Reference	Reference
	Current use	198	4.6	1.92 (1.53–2.42)^‡	1.79 (1.42–2.27)^‡

CHD	General population	5,993	6.6	Reference	Reference
	Current use	1,269	5.4	1.06 (1.00–1.13)*	0.94 (0.87–1.00)*
	Psychiatric nonusers	982	3.5	Reference	Reference
	Current use	1,355	5.7	1.08 (1.00–1.18)*	1.16 (0.94–1.44)

Ventricular arrhythmias	General population	1,977	2.2	Reference	Reference
	Current use	646	2.7	1.53 (1.40–1.67)^‡	1.49 (1.35–1.64)^‡
	Psychiatric nonusers	500	1.8	Reference	Reference
	Current use	646	2.7	1.14 (1.01–1.28)^†	1.16 (1.02–1.31)^†

, ^†, ^‡.