Cardiovascular Psychiatry and Neurology / 2013 / Article / Tab 6

Clinical Study

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Table 6

RR of all-cause mortality (excluding suicide) or cardiac mortality in users of atypical and typical antipsychotics.

OutcomeType of antipsychoticNo. of casesIncidence rate per 1000 person-yearsAge, sex-adjusted relative risk (RR) (95% CI)Fully adjusted RR (aRR) (95% CI)

All-cause mortalityTypical15,33491.5ReferenceReference
Atypical7,55576.00.79 (0.77–0.81)0.83 (0.80–0.85)
Cardiac mortalityTypical1,13017.8ReferenceReference
Atypical1,21416.10.84 (0.78–0.91)0.89 (0.82–0.97)
SCD primary definitionTypical203.8ReferenceReference
SCD secondary definitionTypical7714.5ReferenceReference
Atypical959.10.72 (0.53–0.97)0.76 (0.55–1.04)*
SCD tertiary definitionTypical976.3ReferenceReference
Atypical993.70.66 (0.50–0.87)0.70 (0.53–0.93)
Atypical4595.10.80 (0.72–0.90)0.85 (0.76–0.96)
Ventricular arrhythmiasTypical3822.8ReferenceReference
Atypical2422.70.94 (0.80–1.10)0.93 (0.79–1.10)

, , , #Not calculable due to small number of cases.