Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database
Table 8
Relative risk of all-cause mortality (excluding suicide), cardiac mortality, and sudden cardiac death in users of antipsychotics compared to psychiatric nonuser controls stratified by age and daily dose.
Outcome
Characteristic
No. of cases
Incidence rate per 1000 person-years
Fully adjusted RR (aRR) (95% CI)
All-cause mortality
Age < 30
121
4.5
4.12 (2.72–6.25)‡
Age 30–64
3,473
22.3
2.23 (1.85–2.68)‡
Age 65–79
6,563
127.6
1.78 (1.57–2.02)‡
Age ≥ 80
13,684
322.3
1.43 (1.31–1.55)‡
Cardiac mortality
Age < 30
7
0.4
—(NC#)
Age 30–64
219
2.8
2.39 (1.80–3.19)‡
Age 65–79
682
27.1
1.60 (1.40–1.83)‡
Age ≥ 80
1,570
63.0
1.55 (1.22–1.98)‡
SCD-primary definition
Age < 30
1
0.5
—(NC#)
Age 30–64
8
1.0
—(NC#)
Age 65–79
12
4.5
—(NC#)
Age ≥ 80
23
7.4
—(NC#)
All-cause mortality
Low daily dose
21208
97.0
1.72 (1.62–1.84)‡
Medium daily dose
1978
52.5
1.94 (1.80–2.10)‡
High daily dose
655
31.9
1.89 (1.71–2.09)‡
Cardiac mortality
Low daily dose
2157
20.0
1.65 (1.36–2.00)‡
Medium daily dose
251
9.9
2.10 (1.68–2.63)‡
High daily dose
70
5.6
2.27 (1.68–3.07)‡
SCD-primary definition
Low daily dose
39
3.3
5.87 (2.92–11.78)‡
Medium daily dose
4
1.4
5.51 (1.69–17.96)‡
High daily dose
1
0.8
3.81 (0.47–30.59)
, †, ‡, #Not calculable due to small number of cases.
