Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics

Table 1

Demographic and metabolic characteristics of the schizophrenia, bipolar, and combined samples.

	Schizophrenia spectrum (𝑛=226)	Bipolar disorder (𝑛=94)	Combined (𝑛=320)
Age (year)	42.7±11.6	41.8±12.0	42.5±11.7
Gender (% female)	37	63	44.7^¥
Race (% Caucasian/% African American/% other*)	65/26/9	81/12/7	70/21/9^¥
Current smokers (%)	53	32	47^¥
Currently on AAP (%)	85	74	82^¥
BMI (kg/m^2)	31.4±7.24	31.8±8.89	31.5±7.74
SBP (mmHg)	122±16.0	123±17.7	122±16.5
DBP (mmHg)	74.2±11.4	72.9±11.0	73.8±11.3
TC (mg/dL)	179±41.2	191±45.7	183±42.9^¥
TG (mg/dL)	130±88.9	142±108	134±95.0
HDL (mg/dL)	53.1±17.3	57.6±15.1	54.4±16.8^¥
LDL (mg/dL)	108±34.8	118±38.8	111±36.2^¥
Glucose (mg/dL)	99.0±18.5	95.2±10.7	97.9±16.6
Insulin (µIU/mL)	20.3±14.6	24.3±21.6	21.5±17.0
HOMA-IR	5.07±4.23	5.90±5.66	5.32±4.70

Means ± S.D. or percentage.
AAP: atypical antipsychotic, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, TC: total cholesterol, TG: triglycerides, HDL: high-density lipoprotein, LDL: low-density lipoprotein, and HOMA-IR: homeostasis model assessment-insulin resistance.
∗Other includes self-defined race categories of Asian, Hispanic, latino, and others.
¥Significant difference based on a P value cutoff of 0.05.