Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database

Table 6

Relative risks of all-cause mortality (excluding suicide) and cardiac mortality for current users of various types of antipsychotics versus nonuser psychiatric controls stratified by duration of treatment.

Outcome	Exposure type of current users	Duration of treatment	Outcome events	Person-time (Years)	Incidence rate per 1000 PY; (95% CI)	Fully adjusted RR (aRR); (95% CI)
All-cause mortality	Nonuser psychiatric	NA	7765	307,276	25.3 (24.7–25.8)	Reference
	Atypical or typical	<1 year	16,571	176,402	93.9 (92.5–95.4)	1.95 (1.83–2.08)^‡
		1–3 years	4861	56,041	86.7 (84.3–89.2)	1.53 (1.43–1.64)^‡
		>3 years	2409	44,449	54.2 (52.1–56.4)	1.20 (1.11–1.29)^‡
	Atypical	<1 year	4333	49,387	87.7 (85.1–90.4)	1.68 (1.55–1.82)^‡
		1–3 years	2068	26407	78.3 (75.0–81.8)	1.42 (1.31–1.55)^‡
		>3 years	955	18,318	52.1 (48.9–55.6)	1.15 (1.04–1.27)^‡
	Typical	<1 year	11,989	124,518	96.3 (94.6–98.0)	1.98 (1.84–2.13)^‡
		1–3 years	2430	24,906	97.6 (93.7–101.5)	1.56 (1.43–1.69)^‡
		>3 years	1054	17,581	60.0 (56.4–63.7)	1.17 (1.06–1.28)^‡
	Olanzapine	<1 year	659	18,111	36.4 (33.7–39.3)	1.21 (1.06–1.38)^‡
		1–3 years	395	9674	40.8 (36.9–45.1)	1.04 (0.91–1.20)
		>3 years	251	7200	34.9 (30.7–39.5)	0.78 (0.67–0.91)^‡
Cardiac mortality	Nonuser psychiatric	NA	1289	200,988	6.4 (6.1–6.8)	Reference
	Atypical or typical	<1 year	1707	95,129	17.9 (17.1–18.8)	1.85 (1.53–2.24)^‡
		1–3 years	563	32,383	17.4 (16.0–18.9)	1.60 (1.30–1.95)^‡
		>3 years	208	18,131	11.5 (10.0–13.1)	1.31 (1.04–1.65)^†
	Atypical	<1 year	761	42,705	17.8 (16.6–19.1)	1.51 (1.38–1.66)^‡
		1–3 years	315	20,399	15.4 (13.8–17.2)	1.26 (1.11–1.43)^‡
		>3 years	124	10,180	12.2 (10.1–14.5)	1.16 (0.97–1.41)
	Typical	<1 year	918	50,850	18.1 (16.9–19.3)	1.92 (1.51–2.45)^‡
		1–3 years	204	9216	22.1 (19.2–25.4)	1.75 (1.34–2.28)^‡
		>3 years	58	4848	12.0 (9.1–15.5)	1.21 (0.86–1.71)
	Olanzapine	<1 year	111	15,615	7.1 (5.9–8.6)	1.67 (1.18–2.35)‡
		1–3 years	65	7269	8.9 (6.9–11.4)	1.57 (1.09–2.26)^†
		>3 years	30	3881	7.7 (5.2–11.0)	1.24 (0.79–1.94)

^∗𝑃<0.10, ^†𝑃<0.05, ^‡𝑃<0.01.
Abbreviations: aRR: adjusted relative risk; CI: confidence interval; NC: not calculable; PY: person-years.