Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review

Table 3

Studies investigating cerebral autoregulation during cardiac surgery in conjunction with neurocognitive tests.

Study	Study design	Number of patients	Cerebral autoregulation measures	Time of assessment	Outcome
Patel et al., 1993 [53]	RCT	70	Xenon-133 isotope clearance, CMRO2 (cerebral metabolic rate for oxygen), CERO2 (cerebral extraction ratio for oxygen)	6 weeks	Decline with impaired CA
Patel et al., 1996 [54]	RCT	70	CBF, CBFv, and O2 saturation were measured during 4 phases of surgery	6 weeks	Decline with impaired CA
Govier et al., 1984 [55]	Obsv.	67	Partial pressure of arterial carbon dioxide (PaCO2), clearance of xenon-133	Discharge	No difference
Newman et al., 1994 [12]	Obsv.	215	Xenon-133 clearance, CMRO2, cerebral AV difference (C[AV]O2)	Discharge	No difference

Obsv.: observational.