|
| Study | Study
design | Number of
patients | Marker for cerebral damage | Time of assessment | Outcome |
|
| Fitch et al., 1999 [20] | RCT | 35 | Inhibition of complement activation by specific antibody and no antibody | Discharge | Improved cognition |
| Heyer et al., 2002 [21] | RCT | 99 | Inhibition of complement activation by heparin-coated CPB | 5 days and 6 weeks | Improved cognition |
| Baufreton et al., 2005 [19] | RCT | 30 | Inhibition of complement activation by heparin-coated CPB | Discharge | Improved cognition |
| Skrabal et al., 2006 [22] | RCT | 39 | PMEA-coated circuits and noncoated circuits | 7–10 days | Improved cognition |
| Wimmer-Greinecker et al., 1998 [56] | Obsv. | 76 | >S-100 and NSE | 5 days and 2 months | Decline |
|
Jönsson et al., 1999 [57] | Obsv. | 132 | >S-100 | 2 weeks and 2 months | Decline |
| Kilminster et al., 1999 [58] | Obsv. | 130 | >S-100 | 6–8 weeks | Decline |
| Rasmussen et al., 1999 [59] | Obsv. | 35 | >NSE | Discharge and 3 months | Decline |
| Derkach et al., 2000 [60] | RCT | 27 | >S-100 and NSE (deep and mild hypothermic) | 6 months | Decline |
| Diegeler et al., 2000 [61] | RCT | 40 | >S-100 (on- and off-pump) | 1 week | Decline |
| Georgiadis et al., 2000 [62] | Obsv. | 190 | >S-100 | Discharge | Decline |
|
Lloyd et al., 2000 [63] | RCT | 125 | >S-100 (on- and off-pump) | 3 months | Decline |
| Basile et al., 2001 [64] | Obsv. | 16 | >S-100 and NSE | 6 months | Decline |
| Rasmussen et al., 2002 [65] | Obsv. | 15 | >NSE | Discharge and 3 months | Decline |
| Farsak et al., 2003 [66] | Obsv. | 50 | >S-100 | Discharge | Decline |
| Mathew et al., 2003 [67] | Obsv. | 460 | Reduced preoperative endotoxin immunity | 6 weeks | Decline |
|
Jönsson et al., 2004 [68] | Obsv. | 56 | >S-100 | 6 months | Decline |
| Kofke et al., 2004 [69] | Obsv. | 28 | Apo epsilon 4 allele, >S-100 | 8 and 24 hrs | Decline |
| Snyder-Ramos et al., 2004 [70] | Obsv. | 64 | >S-100 and NSE | Throughout 7 days | Decline |
|
Kálmán et al., 2006 [71] | Obsv. | 14 | >Cytokine interleukin-6 | 1 week and 6 months | Decline |
| Ramlawi et al., 2006 [72] | Obsv. | 42 | >C-reactive protein | 6 hours and 4 days | Decline |
| Lazibat et al., 2012 [24] | Obsv. | 62 | >S-100 | 2 days | Decline |
| Bayram et al., 2013 [25] | Obsv. | 64 | >S-100 | 1 week | Decline |
| Westaby et al., 2001 [26] | Obsv. | 1001 | >S-100 and NSE | 5 days and 3 months | No difference |
| Mathew et al., 2005 [73] | Obsv. | 440 | Statin treatment | 6 weeks | No difference |
| Plaschke et al., 2013 [74] | Obsv. | 151 | Preoperative serum anticholinergic activity | 3 months | No difference |
|
