Effects of Swimming Exercise on Limbic and Motor Cortex Neurogenesis in the Kainate-Lesion Model of Temporal Lobe Epilepsy

Figure 8

Effects of 30 d swimming exercise on morphometric counts of dendritic branch points and intersections in motor cortex. Morphometric cell counts of dendritic branch points and intersections of the surviving neurons in groups of 4-month-old male Wistar rats exposed to the following conditions: normal control (NC), normal control followed by swimming exercise (NC+EX), sham-operated control followed by swimming exercise (SC+EX), and kainic acid-induced lesioning and seizures (LO) followed by swimming exercise (L+EX) treatments. (a) Effects on dendritic branch point counts for immediate (1 d postgrouping for controls, 1 d postictal period for lesioned rats) exposure to the swimming exercise. (b) Effects on dendritic branch point counts for delayed (60 d postgrouping for controls, 60 d postictal period for lesioned rats) exposure to the swimming exercise. (c) Effects on dendritic intersection counts for immediate (1 d postgrouping for controls, 1 d postictal period for lesioned rats) exposure to the swimming exercise. (d) Effects on dendritic intersection counts for delayed (60 d postgrouping for controls, 60 d postictal period for lesioned rats) exposure to the swimming exercise. Bars represent dendritic branching points or intersections in means ± standard errors. Intergroup differences significant at and . -values for (a–d) 324.9, 594, 1000, and 1421, respectively.

(a)

(b)

(c)

(d)