Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2017, Article ID 3674371, 7 pages
https://doi.org/10.1155/2017/3674371
Research Article

Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients

1MD Program, University of Toronto, Toronto, ON, Canada
2Hurvitz Brain Sciences Program, Sunnybrook Research Institute and Department of Psychiatry, University of Toronto, Toronto, ON, Canada
3Centre for Addiction and Mental Health and Departments of Psychiatry and Pharmacology/Toxicology, University of Toronto, Toronto, ON, Canada
4Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada
5Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
6University Health Network at Toronto Rehabilitation Institute, Toronto, ON, Canada
7Hurvitz Brain Sciences Program, Sunnybrook Research Institute and Departments of Psychiatry and Pharmacology/Toxicology, University of Toronto, Toronto, ON, Canada

Correspondence should be addressed to Krista L. Lanctôt; ac.koorbynnus@totcnal.atsirk

Received 17 July 2017; Revised 19 September 2017; Accepted 28 September 2017; Published 2 November 2017

Academic Editor: Janusz K. Rybakowski

Copyright © 2017 Graham Mazereeuw et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients. Methods. This was a secondary analysis of the CAROTID trial (NCT00981383). Composite immediate recall, measured using the California Verbal Learning Test, Second Edition, and the Brief Visuospatial Memory Test-Revised, was assessed. LPH, 4-HNE, 8-ISO, MDA, and n-3 PUFA concentrations were analysed from fasting blood. Patients then received either n-3 PUFA treatment or placebo for 12 weeks, after which composite immediate recall was reassessed. Linear regression was used to investigate relationships between lipid peroxidation markers and changes in composite immediate recall in each treatment group. Results. Eighty-five patients (age = , 77% male, mean years of education = ) were included ( placebo, n-3 PUFA). After adjusting for multiple comparisons and potential confounders, greater baseline concentrations of LPH (β = 0.45, ) and 4-HNE (β = 0.38, ) were associated with greater improvement in composite immediate recall among n-3 PUFA-treated patients. No other associations were observed. Conclusions. N-3 PUFA treatment may be more likely to improve immediate recall in patients with greater oxidative stress.