A Validated High-Performance Liquid Chromatography-Tandem Mass Spectrometric (Lc-Ms/Ms) Method for Simultaneous Determination of R(+)-Ketorolac and S(−)-Ketorolac in Human Plasma and Its Application to a Bioequivalence Study

<table>Linear plot of mean plasma S(−)-ketorolac concentration (ng/ml) versus time (h) in healthy adult human male subjects (<svg height="10.6875" id="M62" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 48.4375 10.6875" width="48.4375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6875)">
<g transform="translate(72,-63.45)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑁</tspan>
<tspan style="font-size: 12.50px; " x="14.103384" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.143772" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="32.395271" y="0">2</tspan>
</text>
</g>
</g>
</svg>).</table>

Chromatography Research International

fig5

Figure 5

Figure 5: A Validated High-Performance Liquid Chromatography-Tandem Mass Spectrometric (Lc-Ms/Ms) Method for Simultaneous Determination of R(+)-Ketorolac and S(−)-Ketorolac in Human Plasma and Its Application to a Bioequivalence Study 

Figure 5 | A Validated High-Performance Liquid Chromatography-Tandem Mass Spectrometric (Lc-Ms/Ms) Method for Simultaneous Determination of R(+)-Ketorolac and S(−)-Ketorolac in Human Plasma and Its Application to a Bioequivalence Study 