Stress Degradation Behavior of Paliperidone, an Antipsychotic Drug, and Development of Suitable Stability-Indicating RP-LC Method

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="256812.fig.003a" src="https://static.hindawi.com/articles/cri/volume-2011/256812/figures/256812.fig.003a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Peroxide-treated test sample</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="256812.fig.003b" src="https://static.hindawi.com/articles/cri/volume-2011/256812/figures/256812.fig.003b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Base-treated test sample</td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="256812.fig.003c" src="https://static.hindawi.com/articles/cri/volume-2011/256812/figures/256812.fig.003c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Acid-treated test sample</td></tr></table></td></tr></table>

<table>Typical RP-HPLC chromatograms of forced degradation; (a) peroxide treated test sample and (b) acid treated test sample, (c) base treated test sample.</table>

Chromatography Research International

fig3

Figure 3

Figure 3: Stress Degradation Behavior of Paliperidone, an Antipsychotic Drug, and Development of Suitable Stability-Indicating RP-LC Method 