Chromatography Research International / 2012 / Article / Fig 5

Research Article

Development and Validation of a Stability Indicating LC Method for the Assay and Related Substances Determination of a Proteasome Inhibitor Bortezomib

Figure 5

Three-dimensional plot of the response surface for ๐‘Œ (found critical resolution-1 between bortezomib and Imp-C), (a) variation of the response ๐‘Œ as a function of A (flow rate) and B (% acetonitrile); fixed factor: C (% methanol) = 80% v/v, (b) variation of the response ๐‘Œ as a function of A (flow rate) and C (% methanol); fixed factor: B (% acetonitrile) = 28.5% v/v, (c) variation of the response ๐‘Œ as a function of B (% acetonitrile) and C (% methanol); fixed factor: A (flow rate) = 1.0 mLโ€‰minโˆ’1.
801720.fig.005a
(a)
801720.fig.005b
(b)
801720.fig.005c
(c)

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