| Matrix | Analyte | Extraction method | Detector system | Sensitivity | References |
| Mass detector | Plasma | SER and N-DSER | LLE | TMS | LOQ = 0.5 ng/mL | [21] | Plasma | FLX and NFLX | LLE | ESI, SIM* | LOQ = 2.5 g/mL for FLX and 10 g/mL NFLX | [25] | Plasma | FLX | SBSE | ESI, SIM | LOQ = 30 pg/mL (liquid desorption) and 1.37 pg/mL (thermal desorption) | [26] | Hair | CIT, DCIT, and DDCIT | LLE | TMS | LOD = 10 pg/mg LOQ = 20 pg/mg | [33] | Plasma | VLF, O-DVLF, N-DVLF N,O-didesmethylvenlafaxine (DDVLF) | LLE | MS | LOD = 0.4, 0.2, 0.3, and 0.2 ng/mL and LLOQ = 3.5, 2.2, 2.7, and 1.9 ng/mL for VLF, O-DVLF, N-DVLF, and DDVLF, respectively | [75] | Plasma | SER | SPE | Triple stage (ESI, SRM) | LOQ = 0.5 ng/mL | [76] | Oral fluid and plasma | FLX, NFLX PAR, SER, FLV, CIT, and VLF | Automated SPE | TMS (ESI), with triple quadrupole | LOQ = 2 ng/mL in oral fluid, 2 ng/mL in plasma (except FLV 10 ng/mL and NFLX 4 ng/mL) | [77] | Plasma | FLX and NFLX | Automated SPE | Triple stage (ESI, SRM) | LLOQ = 0.5 ng/mL | [78] | Plasma | FLX and NFLX | Online extraction using column switching | ESI, SIM | LOQ = 25 ng/mL | [79] | Plasma | VLF and-DVLF | SPE | TMS, SRM | LOQ = 3 ng/mL for VLF, 6 ng/mL for DVLF | [80] | Plasma | CIT | LLE | ESI, SIM | LOQ = 0.50 ng/mL | [81] | Plasma | CIT and DCIT | Deproteinization | MS (SIM) | LOQ = 0.25 to 0.5 ng/mL | [82] | Plasma | FLV, PAR, and MCP | SPE | QMS-(SSI)* | LOD = 0.05 to 0.13 g/mL and LOQ = 0.10 to 0.20 g/mL | [83] | Plasma | FLX and NFLX | LLE | TMS (ESI) | LOQ = 0.15 ng/mL | [84] | Plasma | FLX, CIT, PAR, and VLF | SPE | MS (ESI) | LOD, FLX = 0.5, CIT = 0.3, PAR = 0.3, and VEN = 0.1 ng/mL | [85] | Blood | FLX, PAR, SER, FLV, CIT, VLF, NFLX, DCIT, DDCIT, and DVLF | LLE | TMS | LOD = 5–500 ng/mL and LOQ = 5 ng/mL LOD = 20–2000 ng/mL for VLF and DVLF LOQ = 20 ng/mL for VLF and DVLF | [86] |
| UV detector | Urine and plasma | SER | HF-LPME | UV | LOD = 0.5 g/L LOQ = 2.3 g/L | [18] | Plasma | CIT and DCIT | LLE | UV | LOD = 5 ng/mL | [38] | Plasma | CIT, SER, FLX, PAR, and DLX | SBSE | UV | LOD = 20 ng/mL for CIT and PAR, 25 ng/mL for FLX and SER and 16 ng/mL for DLX | [44] | Plasma | FLX, SER, PAR, and CIT | LLE | UV | LOQ = 10 ng/mL for FLX, SER, and PAR and 5 ng/mL for CIT | [87] | Plasma and urine | FLX, PAR, and VLF | SPE | UV | LOD = 0.2–0.6 ng/L in plasma and 0.1–0.8 ng/L in urine | [88] | Plasma | CIT, FLX, PAR | SPE | UV | LOQ = 0.05 to 0.26 mM | [89] | Plasma | CIT, DCIT, DDCIT, FLV, PAR, SER, FLX, NFLX, VLF, and O-DVLF | LLE | UV | LOQ = 25 ng/mL, 100 ng/mL for VLF and O-DVLF | [90] | Plasma | R- and S-CIT, R- and S-DCIT, and R- and S-DDCIT | LLE | UV | LOD > 2 ng/mL | [91] | Fluorescence detector | Plasma | FLX and NFLX | LLE | FD | LLOD = 3 mg/L | [17] | Plasma | SER and DSER | SPE | FD | LOQ = 1.0 ng/mL and LOD = 0.3 ng/mL | [22] | Plasma | CIT, DCIT, DDCIT | SPE | FD | LOQ = 1.5 to 2 ng/mL | [32] | Plasma, urine, and brain tissue | CIT, DCIT, DDCIT, FLX, NFLX, VLF, and O-DVLF | SBSE | FD | LOQ = 0.2 to 2 mg/L in plasma, 2 to 20 ng/g in brain tissue, and 1 to 10 mg/L in urine | [49] | Serum | SER | LLE | FD | LOQ up to 2 ng/mL | [53] | Plasma | CIT, DCIT, DDCIT, PAR, and PAR metabolites | SPE | FD | LOQ = 0.025 to 0.12 mmol/L | [92] | Serum | CIT, FLX, and NFLX | LLE | FD | LOQ = 50 mg/L | [93] | Plasma | FLX and NFLX | HF-LPME | FD | LOQ = 5 ng/mL | [89] | Plasma | CIT, DCIT, and DDCIT | SPE | FD | LOD = 0.8 nmol/L | [94] |
| Diode array detector | Plasma | FLX, NFLX, SER, PAR, CIT, FLV, VLF, MCP, and DVLF | LLE | DAD | LOD = 2.5 to 5 ng/mL | [95] | Urine | CIT, DCIT, DDCIT, FLX, and NFLX | SPME | DAD | LOD = 0.01–0.09 mg/L | [96] |
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