Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Molecule name</td><td align="center">Chemical name</td><td align="center">Chemical structure</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Guaifenesin </td><td align="center">(+)-3-(2-Methoxyphenoxy)-propane-1,2-diol</td><td align="center"><img alt="315145.tab.001a" src="https://static.hindawi.com/articles/cri/volume-2013/315145/figures/315145.tab.001a.jpg"/></td></tr><tr><td align="left" colspan="3"><hr/></td></tr><tr><td align="left">Dextromethorphan</td><td align="center">Ent-3-methoxy-17-methylmorphinan</td><td align="center"><img alt="315145.tab.001b" src="https://static.hindawi.com/articles/cri/volume-2013/315145/figures/315145.tab.001b.jpg"/></td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Structures of Guaifenesin and Dextromethorphan.

Chromatography Research International

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Table 1

Table 1: Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations 

Table 1 | Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations 